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Mobile genetic elements and cancer. From mutations to gene therapy

Mobile genetic elements and cancer. From mutations to gene therapy

In the present review, an association between cancer and the activity of the non-LTR retroelements L1, Alu, and SVA, as well as endogenous retroviruses, in the human genome, is analyzed. Data suggesting that transposons have been involved in embryogenesis and malignization processes, are presented....

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Bibliographic Details
Main Authors: Kozeretska, I.A., Demydov, S.V., Ostapchenko, L.I.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
Series:Experimental Oncology
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Reviews
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/138667
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Summary:In the present review, an association between cancer and the activity of the non-LTR retroelements L1, Alu, and SVA, as well as endogenous retroviruses, in the human genome, is analyzed. Data suggesting that transposons have been involved in embryogenesis and malignization processes, are presented. Events that lead to the activation of mobile elements in mammalian somatic cells, as well as the use of mobile elements in genetic screening and cancer gene therapy, are reviewed.

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