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The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37

The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37

Aim: to study the activity of antioxidant enzymes and to evaluate an intensity of prooxidant processes in sarcoma 37 (S37) cells during tumor development and under influence of sodium dichloroacetate (SDA). Methods: Activity of total superoxide dismutase (SOD), SOD isoforms, catalase (Cat), glutathi...

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Main Authors: Sorokina, L.V., Pyatchanina, T.V., Didenko, G.V., Kaplia, A.A., Khyzhnyak, S.V.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2011
Series:Experimental Oncology
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Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/138675
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spelling irk-123456789-1386752018-06-20T03:09:43Z The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 Sorokina, L.V. Pyatchanina, T.V. Didenko, G.V. Kaplia, A.A. Khyzhnyak, S.V. Original contributions Aim: to study the activity of antioxidant enzymes and to evaluate an intensity of prooxidant processes in sarcoma 37 (S37) cells during tumor development and under influence of sodium dichloroacetate (SDA). Methods: Activity of total superoxide dismutase (SOD), SOD isoforms, catalase (Cat), glutathione peroxidase (GP), and glutathione reductase (GR), as well as content of reduced glutathione (GSH) and lipid peroxidation (LP) secondary byproducts were determined in S37 homogenated tissues of untreated mice and animals treated with SDA at daily dose of 86 mg/kg. Results: SDA treatment of S37-bearing mice resulted in the reduced activities of total SOD, SOD isoforms (especially Mn-SOD), Cat, GP and significantly decreased GSH content on the background of LP intensification in tumor tissue. Conclusion: The observed changes of oxidative homeostasis in S37-bearing animals treated with SDA could be considered as an element of antitumor action of SDA. 2011 Article The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 / L.V. Sorokina, T.V. Pyatchanina, G.V. Didenko, A.A. Kaplia, S.V. Khyzhnyak // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 216-221. — Бібліогр.: 21 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138675 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Sorokina, L.V.
Pyatchanina, T.V.
Didenko, G.V.
Kaplia, A.A.
Khyzhnyak, S.V.
The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
Experimental Oncology
description Aim: to study the activity of antioxidant enzymes and to evaluate an intensity of prooxidant processes in sarcoma 37 (S37) cells during tumor development and under influence of sodium dichloroacetate (SDA). Methods: Activity of total superoxide dismutase (SOD), SOD isoforms, catalase (Cat), glutathione peroxidase (GP), and glutathione reductase (GR), as well as content of reduced glutathione (GSH) and lipid peroxidation (LP) secondary byproducts were determined in S37 homogenated tissues of untreated mice and animals treated with SDA at daily dose of 86 mg/kg. Results: SDA treatment of S37-bearing mice resulted in the reduced activities of total SOD, SOD isoforms (especially Mn-SOD), Cat, GP and significantly decreased GSH content on the background of LP intensification in tumor tissue. Conclusion: The observed changes of oxidative homeostasis in S37-bearing animals treated with SDA could be considered as an element of antitumor action of SDA.
format Article
author Sorokina, L.V.
Pyatchanina, T.V.
Didenko, G.V.
Kaplia, A.A.
Khyzhnyak, S.V.
author_facet Sorokina, L.V.
Pyatchanina, T.V.
Didenko, G.V.
Kaplia, A.A.
Khyzhnyak, S.V.
author_sort Sorokina, L.V.
title The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
title_short The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
title_full The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
title_fullStr The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
title_full_unstemmed The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
title_sort influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2011
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/138675
citation_txt The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37 / L.V. Sorokina, T.V. Pyatchanina, G.V. Didenko, A.A. Kaplia, S.V. Khyzhnyak // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 216-221. — Бібліогр.: 21 назв. — англ.
series Experimental Oncology
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first_indexed 2023-10-18T21:18:58Z
last_indexed 2023-10-18T21:18:58Z
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