Inhibition of TGFβ signaling and its implications in anticancer treatments
The transforming growth factor-β (TGFβ) is a potent regulator of tumorigenesis. In cancer, two distinctive behaviors of TGFβ have been reported as a tumor suppressor at early stage of the disease, and as a tumor promoter at later stages. The past decades, the dualistic role of TGFβ has garnered a lo...
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| Дата: | 2012 |
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| Автори: | , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138683 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Inhibition of TGFβ signaling and its implications in anticancer treatments / I. Calone, S. Souchelnytskyi // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 9-16. — Бібліогр.: 95 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-1386832018-06-20T03:05:37Z Inhibition of TGFβ signaling and its implications in anticancer treatments Calone, I. Souchelnytskyi, S. Reviews The transforming growth factor-β (TGFβ) is a potent regulator of tumorigenesis. In cancer, two distinctive behaviors of TGFβ have been reported as a tumor suppressor at early stage of the disease, and as a tumor promoter at later stages. The past decades, the dualistic role of TGFβ has garnered a lot of attention. As a result, cancer researchers’ has been tasked to elucidate how TGFβ signaling may lead to metastatic dissemination, how to tackle carcinogenesis and which therapeutic strategies should be adopted. Consequently, TGFβ signaling pathways have been considered as appropriate targets for cancer therapy. The TGFβ therapeutic strategies have emerged at three levels: ligand, ligand-receptor interaction and intracellular signaling level. Promising inhibitors of TGFβ signaling have entered clinical trials and shown encouraging results. Here we review the three strategies of TGFβ signaling inhibition and theirs applications in treatment of cancer. 2012 Article Inhibition of TGFβ signaling and its implications in anticancer treatments / I. Calone, S. Souchelnytskyi // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 9-16. — Бібліогр.: 95 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138683 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
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DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Calone, I. Souchelnytskyi, S. Inhibition of TGFβ signaling and its implications in anticancer treatments Experimental Oncology |
| description |
The transforming growth factor-β (TGFβ) is a potent regulator of tumorigenesis. In cancer, two distinctive behaviors of TGFβ have been reported as a tumor suppressor at early stage of the disease, and as a tumor promoter at later stages. The past decades, the dualistic role of TGFβ has garnered a lot of attention. As a result, cancer researchers’ has been tasked to elucidate how TGFβ signaling may lead to metastatic dissemination, how to tackle carcinogenesis and which therapeutic strategies should be adopted. Consequently, TGFβ signaling pathways have been considered as appropriate targets for cancer therapy. The TGFβ therapeutic strategies have emerged at three levels: ligand, ligand-receptor interaction and intracellular signaling level. Promising inhibitors of TGFβ signaling have entered clinical trials and shown encouraging results. Here we review the three strategies of TGFβ signaling inhibition and theirs applications in treatment of cancer. |
| format |
Article |
| author |
Calone, I. Souchelnytskyi, S. |
| author_facet |
Calone, I. Souchelnytskyi, S. |
| author_sort |
Calone, I. |
| title |
Inhibition of TGFβ signaling and its implications in anticancer treatments |
| title_short |
Inhibition of TGFβ signaling and its implications in anticancer treatments |
| title_full |
Inhibition of TGFβ signaling and its implications in anticancer treatments |
| title_fullStr |
Inhibition of TGFβ signaling and its implications in anticancer treatments |
| title_full_unstemmed |
Inhibition of TGFβ signaling and its implications in anticancer treatments |
| title_sort |
inhibition of tgfβ signaling and its implications in anticancer treatments |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138683 |
| citation_txt |
Inhibition of TGFβ signaling and its implications in anticancer treatments / I. Calone, S. Souchelnytskyi // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 9-16. — Бібліогр.: 95 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:19:14Z |
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