Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals
Aim: Recent studies showed that increased chromosomal damage induced by ionizing radiation is observed among patients with different tumor types. The aim of the study was evaluation of chromosomal radiosensitivity in breast cancer (BC) patients (n = 37) and healthy women (n = 44). Methods: Chromosom...
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| Дата: | 2012 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138684 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals / N.M. Ryabchenko, O.A. Glavin, V.V. Shtefura, M.F. Anikusko // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 121-124. — Бібліогр.: 27 назв. — англ. |
Репозитарії
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irk-123456789-1386842018-06-20T03:06:17Z Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals Ryabchenko, N.M. Glavin, O.A. Shtefura, V.V. Anikusko, M.F. Original contributions Aim: Recent studies showed that increased chromosomal damage induced by ionizing radiation is observed among patients with different tumor types. The aim of the study was evaluation of chromosomal radiosensitivity in breast cancer (BC) patients (n = 37) and healthy women (n = 44). Methods: Chromosomal radiosensitivity was assessed with G0 and G2 assay. For G0 assay lymphocytes were exposed in vitro to 1,5 Gy of X-rays before culture setting. For G2 assay lymphocytes were irradiated with 0,5 Gy of X-rays after 47 h of incubation. Results: Significant differences in mean scores both of G0 and G2 assay between breast cancer patients and controls were observed indicating the increased chromosomal radiosensitivity of lymphocytes of cancer patients. 11% of healthy women and 38% of BC patients were determined to be radiosensitive with G2 assay. Conclusion: Obtained results support the concept of association between elevated individual G2 chromosomal radiosensitivity and predisposition to BC. 2012 Article Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals / N.M. Ryabchenko, O.A. Glavin, V.V. Shtefura, M.F. Anikusko // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 121-124. — Бібліогр.: 27 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138684 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Ryabchenko, N.M. Glavin, O.A. Shtefura, V.V. Anikusko, M.F. Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals Experimental Oncology |
| description |
Aim: Recent studies showed that increased chromosomal damage induced by ionizing radiation is observed among patients with different tumor types. The aim of the study was evaluation of chromosomal radiosensitivity in breast cancer (BC) patients (n = 37) and healthy women (n = 44). Methods: Chromosomal radiosensitivity was assessed with G0 and G2 assay. For G0 assay lymphocytes were exposed in vitro to 1,5 Gy of X-rays before culture setting. For G2 assay lymphocytes were irradiated with 0,5 Gy of X-rays after 47 h of incubation. Results: Significant differences in mean scores both of G0 and G2 assay between breast cancer patients and controls were observed indicating the increased chromosomal radiosensitivity of lymphocytes of cancer patients. 11% of healthy women and 38% of BC patients were determined to be radiosensitive with G2 assay. Conclusion: Obtained results support the concept of association between elevated individual G2 chromosomal radiosensitivity and predisposition to BC. |
| format |
Article |
| author |
Ryabchenko, N.M. Glavin, O.A. Shtefura, V.V. Anikusko, M.F. |
| author_facet |
Ryabchenko, N.M. Glavin, O.A. Shtefura, V.V. Anikusko, M.F. |
| author_sort |
Ryabchenko, N.M. |
| title |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_short |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_full |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_fullStr |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_full_unstemmed |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals |
| title_sort |
chromosomal radiosensitivity in ukrainian breast cancer patients and healthy individuals |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138684 |
| citation_txt |
Chromosomal Radiosensitivity in Ukrainian breast cancer patients and healthy Individuals / N.M. Ryabchenko, O.A. Glavin, V.V. Shtefura, M.F. Anikusko // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 121-124. — Бібліогр.: 27 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:19:14Z |
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2023-10-18T21:19:14Z |
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