Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells
The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye c...
Збережено в:
| Дата: | 2012 |
|---|---|
| Автори: | , , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
|
| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138691 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
irk-123456789-138691 |
|---|---|
| record_format |
dspace |
| spelling |
irk-123456789-1386912018-06-20T03:07:56Z Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells Yefimova, S.L. Kurilchenko, I.Yu. Tkacheva, T.N. Rozhkov, V.A. Sorokin, A.V. Lukianova, N.Yu. Bezdenezhnykh, N.A. Malyukin, Yu.V. Chekhun, V.F. Original contributions The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye cellular uptake in sensitive, cisplatin-resistant and doxorubicin-resistant MCF-7 human breast cancer cells have been analyzed using time changes in both fluorescence resonance energy transfer signal from the donor probe DiO to the acceptor one DiI preloaded in liposomes and cell image brightness. Conclusion: Obtained results show that resistant cells accumulate dye-loaded liposomes more effectively and reveal more effective dye molecule cellular uptake. 2012 Article Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138691 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Yefimova, S.L. Kurilchenko, I.Yu. Tkacheva, T.N. Rozhkov, V.A. Sorokin, A.V. Lukianova, N.Yu. Bezdenezhnykh, N.A. Malyukin, Yu.V. Chekhun, V.F. Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells Experimental Oncology |
| description |
The aim of this research is to study the dynamics and efficiency of liposome accumulation in sensitive and resistant human breast cancer cells. Methods: Methods of fluorescence microscopy, fluorescence microspectroscopy and MTT-test have been used. Results: The liposome-to-cell interaction and dye cellular uptake in sensitive, cisplatin-resistant and doxorubicin-resistant MCF-7 human breast cancer cells have been analyzed using time changes in both fluorescence resonance energy transfer signal from the donor probe DiO to the acceptor one DiI preloaded in liposomes and cell image brightness. Conclusion: Obtained results show that resistant cells accumulate dye-loaded liposomes more effectively and reveal more effective dye molecule cellular uptake. |
| format |
Article |
| author |
Yefimova, S.L. Kurilchenko, I.Yu. Tkacheva, T.N. Rozhkov, V.A. Sorokin, A.V. Lukianova, N.Yu. Bezdenezhnykh, N.A. Malyukin, Yu.V. Chekhun, V.F. |
| author_facet |
Yefimova, S.L. Kurilchenko, I.Yu. Tkacheva, T.N. Rozhkov, V.A. Sorokin, A.V. Lukianova, N.Yu. Bezdenezhnykh, N.A. Malyukin, Yu.V. Chekhun, V.F. |
| author_sort |
Yefimova, S.L. |
| title |
Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_short |
Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_full |
Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_fullStr |
Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_full_unstemmed |
Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| title_sort |
comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138691 |
| citation_txt |
Comparative study of dye-loaded liposome accumulation in sensitive and resistant human breast cancer cells / S.L. Yefimova, I.Yu. Kurilchenko, T.N. Tkacheva, V.A. Rozhkov, A.V. Sorokin, N.Yu. Lukianova, N.A. Bezdenezhnykh, Yu.V. Malyukin, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 101-106. — Бібліогр.: 14 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
AT yefimovasl comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells AT kurilchenkoiyu comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells AT tkachevatn comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells AT rozhkovva comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells AT sorokinav comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells AT lukianovanyu comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells AT bezdenezhnykhna comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells AT malyukinyuv comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells AT chekhunvf comparativestudyofdyeloadedliposomeaccumulationinsensitiveandresistanthumanbreastcancercells |
| first_indexed |
2023-10-18T21:19:15Z |
| last_indexed |
2023-10-18T21:19:15Z |
| _version_ |
1796152500590477312 |