Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate

Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate

Aim: A recently discovered enzyme, indoleamine 2,3-dioxygenase (IDO), is expressed in placenta, dendritic cells and also in many kinds of tumors and in tumor-infiltrating macrophages. By catabolizing tryptophan, IDO causes local depletion of this essential amino acid and excess of kinurenin, and sup...

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Бібліографічні деталі
Дата:2012
Автори: Vasilyeva, E.D., Kaledin, V., Nikolin, V.P., Popova, N.A., Kirilyuk, I.A., Grigor`ev, I.A.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
Назва видання:Experimental Oncology
Теми:
Short communications
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/138692
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate / E.D. Vasilyeva, V. Kaledin, V.P. Nicolin, N.A. Popova, I.A. Kirilyuk, I.A. Grigor`ev // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 66-68. — Бібліогр.: 14 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-138692
record_format dspace
spelling irk-123456789-1386922018-06-20T03:06:40Z Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate Vasilyeva, E.D. Kaledin, V. Nikolin, V.P. Popova, N.A. Kirilyuk, I.A. Grigor`ev, I.A. Short communications Aim: A recently discovered enzyme, indoleamine 2,3-dioxygenase (IDO), is expressed in placenta, dendritic cells and also in many kinds of tumors and in tumor-infiltrating macrophages. By catabolizing tryptophan, IDO causes local depletion of this essential amino acid and excess of kinurenin, and suppresses in situ proliferation and functioning of T lymphocytes. Thus, immune resistance of tumors can be overcome by inhibiting IDO activity. Materials and Methods: C3HA mice immunized with non-syngeneic H-29 tumor were used to study the effect of the IDO inhibitor ethyl pyruvate, under systemic or local (at site of tumor cells localization) administration, on the occurrence and rate of rejection of the second transplants of this tumor. Results: Both systemic and local administration of ethyl pyruvate increases the incidence of and substantially accelerates tumor regression as compared with control. Conclusion: IDO inhibitors impairing immune resistance of tumors may appear useful in leveraging the efficacy of antitumor therapy. 2012 Article Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate / E.D. Vasilyeva, V. Kaledin, V.P. Nicolin, N.A. Popova, I.A. Kirilyuk, I.A. Grigor`ev // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 66-68. — Бібліогр.: 14 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138692 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Short communications
Short communications
spellingShingle Short communications
Short communications
Vasilyeva, E.D.
Kaledin, V.
Nikolin, V.P.
Popova, N.A.
Kirilyuk, I.A.
Grigor`ev, I.A.
Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate
Experimental Oncology
description Aim: A recently discovered enzyme, indoleamine 2,3-dioxygenase (IDO), is expressed in placenta, dendritic cells and also in many kinds of tumors and in tumor-infiltrating macrophages. By catabolizing tryptophan, IDO causes local depletion of this essential amino acid and excess of kinurenin, and suppresses in situ proliferation and functioning of T lymphocytes. Thus, immune resistance of tumors can be overcome by inhibiting IDO activity. Materials and Methods: C3HA mice immunized with non-syngeneic H-29 tumor were used to study the effect of the IDO inhibitor ethyl pyruvate, under systemic or local (at site of tumor cells localization) administration, on the occurrence and rate of rejection of the second transplants of this tumor. Results: Both systemic and local administration of ethyl pyruvate increases the incidence of and substantially accelerates tumor regression as compared with control. Conclusion: IDO inhibitors impairing immune resistance of tumors may appear useful in leveraging the efficacy of antitumor therapy.
format Article
author Vasilyeva, E.D.
Kaledin, V.
Nikolin, V.P.
Popova, N.A.
Kirilyuk, I.A.
Grigor`ev, I.A.
author_facet Vasilyeva, E.D.
Kaledin, V.
Nikolin, V.P.
Popova, N.A.
Kirilyuk, I.A.
Grigor`ev, I.A.
author_sort Vasilyeva, E.D.
title Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate
title_short Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate
title_full Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate
title_fullStr Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate
title_full_unstemmed Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate
title_sort accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2012
topic_facet Short communications
url http://dspace.nbuv.gov.ua/handle/123456789/138692
citation_txt Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate / E.D. Vasilyeva, V. Kaledin, V.P. Nicolin, N.A. Popova, I.A. Kirilyuk, I.A. Grigor`ev // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 66-68. — Бібліогр.: 14 назв. — англ.
series Experimental Oncology
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AT kaledinv acceleratedrejectionofthesecondtransplantsofimmunogenictumorinmiceunderinhibitionofindoleamine23dioxygenaseactivitybyethylpyruvate
AT nikolinvp acceleratedrejectionofthesecondtransplantsofimmunogenictumorinmiceunderinhibitionofindoleamine23dioxygenaseactivitybyethylpyruvate
AT popovana acceleratedrejectionofthesecondtransplantsofimmunogenictumorinmiceunderinhibitionofindoleamine23dioxygenaseactivitybyethylpyruvate
AT kirilyukia acceleratedrejectionofthesecondtransplantsofimmunogenictumorinmiceunderinhibitionofindoleamine23dioxygenaseactivitybyethylpyruvate
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first_indexed 2023-10-18T21:19:15Z
last_indexed 2023-10-18T21:19:15Z
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