The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells
Aim. To perform the comparative study both of qualitative and quantitative content of lipids in parental and drug resistant breast cancer cells. Materials and methods. Parental (MCF-7/S) and resistant to cisplatin (MCF-7/CP) and doxorubicin (MCF-7/Dox) human breast cancer cells were used in the stud...
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| Дата: | 2012 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138697 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells / I.N. Todor, N.Yu. Lukianova, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 97-100. — Бібліогр.: 28 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
irk-123456789-138697 |
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irk-123456789-1386972018-06-20T03:08:16Z The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells Todor, I.N. Lukianova, N.Yu. Chekhun, V.F. Original contributions Aim. To perform the comparative study both of qualitative and quantitative content of lipids in parental and drug resistant breast cancer cells. Materials and methods. Parental (MCF-7/S) and resistant to cisplatin (MCF-7/CP) and doxorubicin (MCF-7/Dox) human breast cancer cells were used in the study. Cholesterol, total lipids and phospholipids content were determined by means of thin-layer chromatography. Results. It was found that cholesterol as well as cholesterol ethers content are significantly higher but diacylglycerols, triacylglycerols content are significantly lower in resistant cell strains than in parental (sensitive) cells. Moreover the analysis of individual phospholipids showed the increase of sphingomyelin, phosphatidylserine, cardiolipin, phosphatidic acid and the decrease of phosphatidylethanolamine, phosphatidylcholine in MCF-7/CP and MCF-7/Dox cells. Conclusion. Obtained results allow to suggest that the lipid profile changes can mediate the modulation of membrane fluidity in drug resistant MCF-7 breast cancer cells. 2012 Article The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells / I.N. Todor, N.Yu. Lukianova, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 97-100. — Бібліогр.: 28 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138697 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Todor, I.N. Lukianova, N.Yu. Chekhun, V.F. The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells Experimental Oncology |
| description |
Aim. To perform the comparative study both of qualitative and quantitative content of lipids in parental and drug resistant breast cancer cells. Materials and methods. Parental (MCF-7/S) and resistant to cisplatin (MCF-7/CP) and doxorubicin (MCF-7/Dox) human breast cancer cells were used in the study. Cholesterol, total lipids and phospholipids content were determined by means of thin-layer chromatography. Results. It was found that cholesterol as well as cholesterol ethers content are significantly higher but diacylglycerols, triacylglycerols content are significantly lower in resistant cell strains than in parental (sensitive) cells. Moreover the analysis of individual phospholipids showed the increase of sphingomyelin, phosphatidylserine, cardiolipin, phosphatidic acid and the decrease of phosphatidylethanolamine, phosphatidylcholine in MCF-7/CP and MCF-7/Dox cells. Conclusion. Obtained results allow to suggest that the lipid profile changes can mediate the modulation of membrane fluidity in drug resistant MCF-7 breast cancer cells. |
| format |
Article |
| author |
Todor, I.N. Lukianova, N.Yu. Chekhun, V.F. |
| author_facet |
Todor, I.N. Lukianova, N.Yu. Chekhun, V.F. |
| author_sort |
Todor, I.N. |
| title |
The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells |
| title_short |
The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells |
| title_full |
The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells |
| title_fullStr |
The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells |
| title_full_unstemmed |
The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells |
| title_sort |
lipid content of cisplatin- and doxorubicin-resistant mcf-7 human breast cancer cells |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138697 |
| citation_txt |
The lipid content of cisplatin- and doxorubicin-resistant MCF-7 human breast cancer cells / I.N. Todor, N.Yu. Lukianova, V.F. Chekhun // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 97-100. — Бібліогр.: 28 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:19:16Z |
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