Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model
Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell...
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| Дата: | 2012 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138719 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model / M.J. Rico, V.R. Rozados, L.E. Mainetti, M.F. Zacarias Fluck, P. Matar, O.G. Scharovsky // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 38-42. — Бібліогр.: 36 назв. — англ. |
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irk-123456789-1387192018-06-20T03:04:59Z Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model Rico, M.J. Rozados, V.R. Mainetti, L.E. Zacarias Fluck, M.F. Matar, P. Scharovsky, O.G. Original contributions Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell populations of the innate immune response with opposing effects on the tumors, in a rat B cell lymphoma model. Methods: Inbred e rats were challenged s.c. with L-TACB lymphoma and on day 14 animals were distributed in two groups. Treated: injected i.p. with cyclophosphamide (10mg/kg of body weight) and Control: injected i.p. with saline. Blood samples were taken from days 0 to 21 and the percentage of T regulatory and natural killer T I cells were determined by flow cytometry. Results: We found that the increase of natural and inducible T regulatory cells of peripheral blood achieved during tumor growth was significantly downregulated by cyclophosphamide. On the contrary, natural killer T I cells were not modulated by the treatment. Conclusion: The antimetastatic effect of a single low dose of Cy would be due, at least in part, to downregulation of natural and inducible T regulatory cells. 2012 Article Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model / M.J. Rico, V.R. Rozados, L.E. Mainetti, M.F. Zacarias Fluck, P. Matar, O.G. Scharovsky // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 38-42. — Бібліогр.: 36 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138719 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Rico, M.J. Rozados, V.R. Mainetti, L.E. Zacarias Fluck, M.F. Matar, P. Scharovsky, O.G. Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model Experimental Oncology |
| description |
Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell populations of the innate immune response with opposing effects on the tumors, in a rat B cell lymphoma model. Methods: Inbred e rats were challenged s.c. with L-TACB lymphoma and on day 14 animals were distributed in two groups. Treated: injected i.p. with cyclophosphamide (10mg/kg of body weight) and Control: injected i.p. with saline. Blood samples were taken from days 0 to 21 and the percentage of T regulatory and natural killer T I cells were determined by flow cytometry. Results: We found that the increase of natural and inducible T regulatory cells of peripheral blood achieved during tumor growth was significantly downregulated by cyclophosphamide. On the contrary, natural killer T I cells were not modulated by the treatment. Conclusion: The antimetastatic effect of a single low dose of Cy would be due, at least in part, to downregulation of natural and inducible T regulatory cells. |
| format |
Article |
| author |
Rico, M.J. Rozados, V.R. Mainetti, L.E. Zacarias Fluck, M.F. Matar, P. Scharovsky, O.G. |
| author_facet |
Rico, M.J. Rozados, V.R. Mainetti, L.E. Zacarias Fluck, M.F. Matar, P. Scharovsky, O.G. |
| author_sort |
Rico, M.J. |
| title |
Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model |
| title_short |
Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model |
| title_full |
Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model |
| title_fullStr |
Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model |
| title_full_unstemmed |
Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model |
| title_sort |
regulatory t cells but not nkt i cells are modulated by a single low-dose cyclophosphamide in a b cell lymphoma tumor-model |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138719 |
| citation_txt |
Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model / M.J. Rico, V.R. Rozados, L.E. Mainetti, M.F. Zacarias Fluck, P. Matar, O.G. Scharovsky // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 38-42. — Бібліогр.: 36 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:19:18Z |
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