Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India
Background:Acute lymphoblastic leukemia (ALL) is the most worldwide common type of childhood cancer. Methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) participate in folate pathways and are known as critical factors for DNA integrity as wel...
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| Дата: | 2012 |
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| Автори: | , , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138722 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India / M. Nikbakht, K. MalekZadeh, A. Kumar Jha, M. Askari, R.K. Marwaha, D. Kaul, J. Kaur // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 43-48. — Бібліогр.: 44 назв. — англ. |
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irk-123456789-1387222018-06-20T03:05:57Z Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India Nikbakht, M. MalekZadeh, K. Kumar Jha, A. Askari, M. Marwaha, R.K. Kaul, D. Kaur, J. Original contributions Background:Acute lymphoblastic leukemia (ALL) is the most worldwide common type of childhood cancer. Methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) participate in folate pathways and are known as critical factors for DNA integrity as well as DNA hypomethylation. The aim of this work is to investigate frequency of MTHFR (677C→T and 1298A→C) and MTR (2756A→G) polymorphisms and their interaction with respect to possible effect on risk of childhood ALL among North Indian population. Procedure: A case control study from has been conducted on bone marrow and peripheral blood samples from 125 ALL patients and 100 sex-age matched healthy controls using PCR-RFLP method. Results: No statistically significant differences were observed for different genotypes between patients and controls (p>0.05). Significant difference for the risk of ALL in individuals having genotype of MTHFR 677TT (OR=0.61, 95% CI=0.21–1.77) and MTHFR 1298CC (OR=0.56, 95% CI=0.18–1.68) was not observed. The correlation of SNP of MTR gene and risk of ALL was not observed, too. Conclusions: The differences in distribution of possible combined genotypes of MTHFR (677C→T, 1298A→C) and MTR (2756A→G) between ALL patients and controls were statistically insignificant. 2012 Article Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India / M. Nikbakht, K. MalekZadeh, A. Kumar Jha, M. Askari, R.K. Marwaha, D. Kaul, J. Kaur // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 43-48. — Бібліогр.: 44 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138722 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Nikbakht, M. MalekZadeh, K. Kumar Jha, A. Askari, M. Marwaha, R.K. Kaul, D. Kaur, J. Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India Experimental Oncology |
| description |
Background:Acute lymphoblastic leukemia (ALL) is the most worldwide common type of childhood cancer. Methylenetetrahydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) participate in folate pathways and are known as critical factors for DNA integrity as well as DNA hypomethylation. The aim of this work is to investigate frequency of MTHFR (677C→T and 1298A→C) and MTR (2756A→G) polymorphisms and their interaction with respect to possible effect on risk of childhood ALL among North Indian population. Procedure: A case control study from has been conducted on bone marrow and peripheral blood samples from 125 ALL patients and 100 sex-age matched healthy controls using PCR-RFLP method. Results: No statistically significant differences were observed for different genotypes between patients and controls (p>0.05). Significant difference for the risk of ALL in individuals having genotype of MTHFR 677TT (OR=0.61, 95% CI=0.21–1.77) and MTHFR 1298CC (OR=0.56, 95% CI=0.18–1.68) was not observed. The correlation of SNP of MTR gene and risk of ALL was not observed, too. Conclusions: The differences in distribution of possible combined genotypes of MTHFR (677C→T, 1298A→C) and MTR (2756A→G) between ALL patients and controls were statistically insignificant. |
| format |
Article |
| author |
Nikbakht, M. MalekZadeh, K. Kumar Jha, A. Askari, M. Marwaha, R.K. Kaul, D. Kaur, J. |
| author_facet |
Nikbakht, M. MalekZadeh, K. Kumar Jha, A. Askari, M. Marwaha, R.K. Kaul, D. Kaur, J. |
| author_sort |
Nikbakht, M. |
| title |
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_short |
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_full |
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_fullStr |
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_full_unstemmed |
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India |
| title_sort |
polymorphisms of mthfr and mtr genes are not related to susceptibility to childhood all in north india |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138722 |
| citation_txt |
Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in north India / M. Nikbakht, K. MalekZadeh, A. Kumar Jha, M. Askari, R.K. Marwaha, D. Kaul, J. Kaur // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 43-48. — Бібліогр.: 44 назв. — англ. |
| series |
Experimental Oncology |
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