Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients
Background and Aim: Endoglin is a proliferation-associated antigen on endothelial cells and essential for angiogenesis. Soluble endoglin (s‑endoglin), formed by proteolytic cleavage of ectodomain of membrane receptor could be an indicator of tumor‑activated endothelium. The aim of present study was...
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| Дата: | 2012 |
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| Автори: | , , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138724 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients / E. Kopczynska, M. Dancewicz, J. Kowalewski, R. Makarewicz, H. Kardymowicz, A. Kaczmarczyk, T. Tyrakowski // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 53-56. — Бібліогр.: 31 назв. — англ. |
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irk-123456789-1387242018-06-20T03:06:31Z Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients Kopczynska, E. Dancewicz, M. Kowalewski, J. Makarewicz, R. Kardymowicz, H. Kaczmarczyk, A. Tyrakowski, T. Original contributions Background and Aim: Endoglin is a proliferation-associated antigen on endothelial cells and essential for angiogenesis. Soluble endoglin (s‑endoglin), formed by proteolytic cleavage of ectodomain of membrane receptor could be an indicator of tumor‑activated endothelium. The aim of present study was to analyze changes of s‑endoglin level in plasma of lung cancer patients following surgical resection and to estimate the correlation of s‑endoglin with other soluble receptors, sTie2 and sVEGF R1. Patients and Methods: The study group consisted of 37 patients with stage I of non-small cell lung cancer. Plasma concentrations of s‑endoglin, sTie2 and sVEGF R1 were evaluated by ELISA, three times: before surgical resection and on postoperative day 7 and 30. Results: The median of s‑endoglin concentration decreased significantly on postoperative day 7 when compared with preoperative level and next increased on 30th day and it was comparable with that before surgery. s-Endoglin correlated with another soluble receptors, with sTie2 both before surgery (r=0.44) and on postoperative day 7 (r=0.52) and on 30th day (r=0.58), with sVEGF R1 — only on postoperative day 7 (r=0.75). Conclusion: The increased level of serum endoglin in lung cancer patients compared to controls and its changes after surgical treatment suggest potential application of soluble form of endoglin as potential tumor marker. 2012 Article Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients / E. Kopczynska, M. Dancewicz, J. Kowalewski, R. Makarewicz, H. Kardymowicz, A. Kaczmarczyk, T. Tyrakowski // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 53-56. — Бібліогр.: 31 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138724 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Kopczynska, E. Dancewicz, M. Kowalewski, J. Makarewicz, R. Kardymowicz, H. Kaczmarczyk, A. Tyrakowski, T. Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients Experimental Oncology |
| description |
Background and Aim: Endoglin is a proliferation-associated antigen on endothelial cells and essential for angiogenesis. Soluble endoglin (s‑endoglin), formed by proteolytic cleavage of ectodomain of membrane receptor could be an indicator of tumor‑activated endothelium. The aim of present study was to analyze changes of s‑endoglin level in plasma of lung cancer patients following surgical resection and to estimate the correlation of s‑endoglin with other soluble receptors, sTie2 and sVEGF R1. Patients and Methods: The study group consisted of 37 patients with stage I of non-small cell lung cancer. Plasma concentrations of s‑endoglin, sTie2 and sVEGF R1 were evaluated by ELISA, three times: before surgical resection and on postoperative day 7 and 30. Results: The median of s‑endoglin concentration decreased significantly on postoperative day 7 when compared with preoperative level and next increased on 30th day and it was comparable with that before surgery. s-Endoglin correlated with another soluble receptors, with sTie2 both before surgery (r=0.44) and on postoperative day 7 (r=0.52) and on 30th day (r=0.58), with sVEGF R1 — only on postoperative day 7 (r=0.75). Conclusion: The increased level of serum endoglin in lung cancer patients compared to controls and its changes after surgical treatment suggest potential application of soluble form of endoglin as potential tumor marker. |
| format |
Article |
| author |
Kopczynska, E. Dancewicz, M. Kowalewski, J. Makarewicz, R. Kardymowicz, H. Kaczmarczyk, A. Tyrakowski, T. |
| author_facet |
Kopczynska, E. Dancewicz, M. Kowalewski, J. Makarewicz, R. Kardymowicz, H. Kaczmarczyk, A. Tyrakowski, T. |
| author_sort |
Kopczynska, E. |
| title |
Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_short |
Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_full |
Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_fullStr |
Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_full_unstemmed |
Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients |
| title_sort |
influence of surgical resection no plasma endoglin (cd105) level in non-small cell lung cancer patients |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138724 |
| citation_txt |
Influence of surgical resection no plasma Endoglin (CD105) level in non-small cell lung cancer patients / E. Kopczynska, M. Dancewicz, J. Kowalewski, R. Makarewicz, H. Kardymowicz, A. Kaczmarczyk, T. Tyrakowski // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 53-56. — Бібліогр.: 31 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:19:19Z |
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2023-10-18T21:19:19Z |
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