Caspase-8 regulation of TRAIL-mediated cell death
Research on TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors has advanced tremendously over the past 17 years. Initial observations of TRAIL and TRAIL receptor-mediated tumor cell toxicity led to enthusiasm of exploiting this selective, malignant cell killing for cancer therapy. Fur...
Збережено в:
| Дата: | 2012 |
|---|---|
| Автори: | , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
|
| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/138727 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Caspase-8 regulation of TRAIL-mediated cell death / R.N. Crowder, W.S. El-Deiry // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 160-164. — Бібліогр.: 49 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
irk-123456789-138727 |
|---|---|
| record_format |
dspace |
| spelling |
irk-123456789-1387272018-06-20T03:08:57Z Caspase-8 regulation of TRAIL-mediated cell death Crowder, R.N. El-Deiry, W.S. Reviews Research on TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors has advanced tremendously over the past 17 years. Initial observations of TRAIL and TRAIL receptor-mediated tumor cell toxicity led to enthusiasm of exploiting this selective, malignant cell killing for cancer therapy. Further examination revealed aberrant TRAIL signaling in some cancer cells leading to protection from TRAIL-mediated cell death. Mechanisms of TRAIL resistance often involve decreased expression or activity of initiator caspase-8, crucial for complete TRAIL signal transduction. Caspase-8 mutations, epigenetic silencing, decrease in stability, and incomplete activation have been reported. This article reviews the discovery of TRAIL and TRAIL receptors and subsequent studies that reveal how expression and function of caspase-8 are central to TRAIL-mediated cell death. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. 2012 Article Caspase-8 regulation of TRAIL-mediated cell death / R.N. Crowder, W.S. El-Deiry // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 160-164. — Бібліогр.: 49 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138727 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Crowder, R.N. El-Deiry, W.S. Caspase-8 regulation of TRAIL-mediated cell death Experimental Oncology |
| description |
Research on TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors has advanced tremendously over the past 17 years. Initial observations of TRAIL and TRAIL receptor-mediated tumor cell toxicity led to enthusiasm of exploiting this selective, malignant cell killing for cancer therapy. Further examination revealed aberrant TRAIL signaling in some cancer cells leading to protection from TRAIL-mediated cell death. Mechanisms of TRAIL resistance often involve decreased expression or activity of initiator caspase-8, crucial for complete TRAIL signal transduction. Caspase-8 mutations, epigenetic silencing, decrease in stability, and incomplete activation have been reported. This article reviews the discovery of TRAIL and TRAIL receptors and subsequent studies that reveal how expression and function of caspase-8 are central to TRAIL-mediated cell death. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. |
| format |
Article |
| author |
Crowder, R.N. El-Deiry, W.S. |
| author_facet |
Crowder, R.N. El-Deiry, W.S. |
| author_sort |
Crowder, R.N. |
| title |
Caspase-8 regulation of TRAIL-mediated cell death |
| title_short |
Caspase-8 regulation of TRAIL-mediated cell death |
| title_full |
Caspase-8 regulation of TRAIL-mediated cell death |
| title_fullStr |
Caspase-8 regulation of TRAIL-mediated cell death |
| title_full_unstemmed |
Caspase-8 regulation of TRAIL-mediated cell death |
| title_sort |
caspase-8 regulation of trail-mediated cell death |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138727 |
| citation_txt |
Caspase-8 regulation of TRAIL-mediated cell death / R.N. Crowder, W.S. El-Deiry // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 160-164. — Бібліогр.: 49 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
AT crowderrn caspase8regulationoftrailmediatedcelldeath AT eldeiryws caspase8regulationoftrailmediatedcelldeath |
| first_indexed |
2023-10-18T21:19:26Z |
| last_indexed |
2023-10-18T21:19:26Z |
| _version_ |
1796152507711356928 |