Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release

In mammalian cells, the mitochondrial pathway of apoptosis plays a key role in various biological processes and has been extensively studied. One of the signature features of this pathway is permeabilization of the outer mitochondrial membrane (MOMP) and thus release of cytochrome c into the cytopla...

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Бібліографічні деталі
Дата:2012
Автори: Monian, P., Jiang, X.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
Назва видання:Experimental Oncology
Теми:
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/138731
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release / P. Monian, X. Jiang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 185-191. — Бібліогр.: 117 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-138731
record_format dspace
spelling irk-123456789-1387312018-06-20T03:05:03Z Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release Monian, P. Jiang, X. Reviews In mammalian cells, the mitochondrial pathway of apoptosis plays a key role in various biological processes and has been extensively studied. One of the signature features of this pathway is permeabilization of the outer mitochondrial membrane (MOMP) and thus release of cytochrome c into the cytoplasm to trigger subsequent activation of executioner caspases. Because MOMP is associated with loss of mitochondrial function, it has long been believed to represent an irreversible commitment to cell death. However, emerging data over the last decade has indicated that induction of MOMP alone is not always sufficient to fully commit cells to death. As such, it becomes important to understand how apoptosis is regulated post-MOMP. Here we recount evidence investigating if and how cells can survive MOMP, and why this might have important physiological consequences. Furthermore, we review recent progress made in understanding how the pathway is regulated beyond MOMP and cytochrome c release. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. 2012 Article Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release / P. Monian, X. Jiang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 185-191. — Бібліогр.: 117 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138731 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Reviews
Reviews
spellingShingle Reviews
Reviews
Monian, P.
Jiang, X.
Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release
Experimental Oncology
description In mammalian cells, the mitochondrial pathway of apoptosis plays a key role in various biological processes and has been extensively studied. One of the signature features of this pathway is permeabilization of the outer mitochondrial membrane (MOMP) and thus release of cytochrome c into the cytoplasm to trigger subsequent activation of executioner caspases. Because MOMP is associated with loss of mitochondrial function, it has long been believed to represent an irreversible commitment to cell death. However, emerging data over the last decade has indicated that induction of MOMP alone is not always sufficient to fully commit cells to death. As such, it becomes important to understand how apoptosis is regulated post-MOMP. Here we recount evidence investigating if and how cells can survive MOMP, and why this might have important physiological consequences. Furthermore, we review recent progress made in understanding how the pathway is regulated beyond MOMP and cytochrome c release. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
format Article
author Monian, P.
Jiang, X.
author_facet Monian, P.
Jiang, X.
author_sort Monian, P.
title Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release
title_short Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release
title_full Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release
title_fullStr Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release
title_full_unstemmed Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release
title_sort clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome c release
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2012
topic_facet Reviews
url http://dspace.nbuv.gov.ua/handle/123456789/138731
citation_txt Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release / P. Monian, X. Jiang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 185-191. — Бібліогр.: 117 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT monianp clearingthefinalhurdlestomitochondrialapoptosisregulationpostcytochromecrelease
AT jiangx clearingthefinalhurdlestomitochondrialapoptosisregulationpostcytochromecrelease
first_indexed 2023-10-18T21:19:26Z
last_indexed 2023-10-18T21:19:26Z
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