Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma

Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma

Aim: To study anticancer activity of аconitine-containing agent BC1 in vivo. Methods: BC1 water solution was administered per os to mice bearing ascite or solid form of Ehrlich’s carcinoma. Anticancer effect of BC1 administered per os was evaluated by the indexes of tumor growth inhibition and avera...

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Збережено в:
Бібліографічні деталі
Дата:2007
Автори: Dasyukevich, O.I., Solyanik, G.I.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2007
Назва видання:Experimental Oncology
Теми:
Short communications
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/139012
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma / O.I. Dasyukevich, G.I. Solyanik // Experimental Oncology. — 2007. — Т. 29, № 4. — С. 317-319. — Бібліогр.: 11 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1390122018-06-20T03:06:18Z Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma Dasyukevich, O.I. Solyanik, G.I. Short communications Aim: To study anticancer activity of аconitine-containing agent BC1 in vivo. Methods: BC1 water solution was administered per os to mice bearing ascite or solid form of Ehrlich’s carcinoma. Anticancer effect of BC1 administered per os was evaluated by the indexes of tumor growth inhibition and average life span of experimental animals. Results: BC1 didn’t show anticancer activity in the case of ascite form of Ehrlich’s carcinoma. At the same time treatment with BC1 resulted in 77.3% growth inhibition of solid form of Ehrlich’s carcinoma (p < 0.05). Conclusion: BC1 is active in vivo against tumor with angiogenesis-dependent growth. Цель: изучить противоопухолевую активность аконитинсодержащего агента ВС1 in vivo.Методы: асцитную и солидную формы карциномы Эрлиха перевивали белым беспородным мышам внутрибрюшинно и подкожно соответственно. Противоопухолевую активность ВС1 оценивали по показателям ингибирования роста опухоли и средней продолжительности жизни животных. Результаты: ВС1 не оказывал противоопухолевого действия в отношении асцитной формы карциномы Эрлиха, но был активен против солидной формы, приводя к 77,3% ингибированию роста опухоли (p < 0,05). Выводы: ВС1 оказывает выраженное противоопухолевое действие в отношении злокачественных новообразований с ангиогенеззависимым ростом. 2007 Article Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma / O.I. Dasyukevich, G.I. Solyanik // Experimental Oncology. — 2007. — Т. 29, № 4. — С. 317-319. — Бібліогр.: 11 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139012 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Short communications
Short communications
spellingShingle Short communications
Short communications
Dasyukevich, O.I.
Solyanik, G.I.
Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma
Experimental Oncology
description Aim: To study anticancer activity of аconitine-containing agent BC1 in vivo. Methods: BC1 water solution was administered per os to mice bearing ascite or solid form of Ehrlich’s carcinoma. Anticancer effect of BC1 administered per os was evaluated by the indexes of tumor growth inhibition and average life span of experimental animals. Results: BC1 didn’t show anticancer activity in the case of ascite form of Ehrlich’s carcinoma. At the same time treatment with BC1 resulted in 77.3% growth inhibition of solid form of Ehrlich’s carcinoma (p < 0.05). Conclusion: BC1 is active in vivo against tumor with angiogenesis-dependent growth.
format Article
author Dasyukevich, O.I.
Solyanik, G.I.
author_facet Dasyukevich, O.I.
Solyanik, G.I.
author_sort Dasyukevich, O.I.
title Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma
title_short Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma
title_full Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma
title_fullStr Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma
title_full_unstemmed Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma
title_sort comparative study of anticancer efficacy of aсonitinecontaining agent bc1 against ascite and solid forms of ehrlich’s carcinoma
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2007
topic_facet Short communications
url http://dspace.nbuv.gov.ua/handle/123456789/139012
citation_txt Comparative study of anticancer efficacy of aсonitinecontaining agent BC1 against ascite and solid forms of Ehrlich’s carcinoma / O.I. Dasyukevich, G.I. Solyanik // Experimental Oncology. — 2007. — Т. 29, № 4. — С. 317-319. — Бібліогр.: 11 назв. — англ.
series Experimental Oncology
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AT solyanikgi comparativestudyofanticancerefficacyofasonitinecontainingagentbc1againstasciteandsolidformsofehrlichscarcinoma
first_indexed 2023-10-18T21:19:33Z
last_indexed 2023-10-18T21:19:33Z
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