A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo
Aim: To analyze possible mechanisms of anticancer activity of hydrobromide 5-(5’,6’-benzocoumaroyl-3’)-methylaminouracil (BCU) in vivo. Methods: BCU was administered at the dose of 6 mg/kg for seven days to rats bearing Guerin carcinoma (Gc). Interaction of BCU with DNA isolated from Gc cells was an...
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| Дата: | 2007 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2007
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/139018 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo / H.P. Kopylchuk, I.O. Shmarakov, M.M. Marchenko // Experimental Oncology. — 2007. — Т. 29, № 4. — С. 320–322. — Бібліогр.: 14 назв. — англ. |
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irk-123456789-1390182018-06-20T03:10:21Z A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo Kopylchuk, H.P. Shmarakov, I.O. Marchenko, M.M. Short communications Aim: To analyze possible mechanisms of anticancer activity of hydrobromide 5-(5’,6’-benzocoumaroyl-3’)-methylaminouracil (BCU) in vivo. Methods: BCU was administered at the dose of 6 mg/kg for seven days to rats bearing Guerin carcinoma (Gc). Interaction of BCU with DNA isolated from Gc cells was analyzed by electrophoresis and spectrophotometry. Results: It has been shown that BCU administration resulted in chromatin condensation, nuclei picnosis, increase of the DNase activity and the appearance of high-molecular DNA fragments in Gc cells. Conclusion: BCU is shown to be able to interact directly with DNA molecules with the formation of stable complexes. Цель: проаналаизировать возможные механизмы противоопухолевой активности гидробромида 5-(5’,6’-бензокумариoл-3’)- метиламиноурацила (BCU) in vivo. Методы: BCU вводили в дозе 6 мг/кг в течение 7 дней крысам с трансплантированной карциномой Герена (КГ). Взаимодействие BCU с ДНК, выделенной из клеток КГ, анализировали методами электрофореза и спектрофотометрии. Результаты: установлено, что введение BCU приводит к конденсации хроматина, пикнозу ядер, повышению ДНКазной активности и появлению высокомолекулярных фрагментов ДНК в клетках КГ. Выводы: BCU может прямо взаимодействовать с молекулами ДНК с образованием стабильных комплексов. 2007 Article A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo / H.P. Kopylchuk, I.O. Shmarakov, M.M. Marchenko // Experimental Oncology. — 2007. — Т. 29, № 4. — С. 320–322. — Бібліогр.: 14 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139018 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Kopylchuk, H.P. Shmarakov, I.O. Marchenko, M.M. A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo Experimental Oncology |
| description |
Aim: To analyze possible mechanisms of anticancer activity of hydrobromide 5-(5’,6’-benzocoumaroyl-3’)-methylaminouracil (BCU) in vivo. Methods: BCU was administered at the dose of 6 mg/kg for seven days to rats bearing Guerin carcinoma (Gc). Interaction of BCU with DNA isolated from Gc cells was analyzed by electrophoresis and spectrophotometry. Results: It has been shown that BCU administration resulted in chromatin condensation, nuclei picnosis, increase of the DNase activity and the appearance of high-molecular DNA fragments in Gc cells. Conclusion: BCU is shown to be able to interact directly with DNA molecules with the formation of stable complexes. |
| format |
Article |
| author |
Kopylchuk, H.P. Shmarakov, I.O. Marchenko, M.M. |
| author_facet |
Kopylchuk, H.P. Shmarakov, I.O. Marchenko, M.M. |
| author_sort |
Kopylchuk, H.P. |
| title |
A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo |
| title_short |
A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo |
| title_full |
A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo |
| title_fullStr |
A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo |
| title_full_unstemmed |
A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo |
| title_sort |
possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2007 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/139018 |
| citation_txt |
A possible mechanism of antitumor activity of 5 (5’,6’ benzocoumaroyl-3’)-methylaminouracil in vivo / H.P. Kopylchuk, I.O. Shmarakov, M.M. Marchenko // Experimental Oncology. — 2007. — Т. 29, № 4. — С. 320–322. — Бібліогр.: 14 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:19:33Z |
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2023-10-18T21:19:33Z |
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