Apoptosis in radiation therapy: a double-edged sword

Radiation therapy achieves its therapeutic effects by inducing apoptosis and non-apoptotic cell death. The aim of this focused review is to highlight the aspects of the cell death pathways most relevant to conventional fractionated radiation therapy. I review reports on how our current understanding...

Повний опис

Збережено в:
Бібліографічні деталі
Дата:2012
Автор: Balcer-Kubiczek, E.K.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
Назва видання:Experimental Oncology
Теми:
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/139044
Теги: Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Apoptosis in radiation therapy: a double-edged sword / E.K. Balcer-Kubiczek // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 277-285. — Бібліогр.: 124 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-139044
record_format dspace
spelling irk-123456789-1390442018-06-20T03:09:16Z Apoptosis in radiation therapy: a double-edged sword Balcer-Kubiczek, E.K. Reviews Radiation therapy achieves its therapeutic effects by inducing apoptosis and non-apoptotic cell death. The aim of this focused review is to highlight the aspects of the cell death pathways most relevant to conventional fractionated radiation therapy. I review reports on how our current understanding of the molecular mechanisms of cell death may enable us to revise the four radiobiological principles (reoxygenation, repair of sublethal damage, redistribution of cells in the cell cycle, and repopulation of surviving cells) for radiation treatment with fractionated dose delivery. Apoptosis and non-apoptotic forms of cell death are not represented in the linear quadratic model, which is clinically used to calculate the effects of different total doses, dose per fraction and fraction number on reproductive cell death, a mode of cell death associated with lethal chromosome aberrations. Examples are provided to justify or not a reassessment of the role of apoptosis and non-apoptotic cell death in radiosensitivity, tumor cell proliferation and tumor microenvironment. As our understanding of apoptosis developed at the molecular level, so did our understanding of other forms of cell death, particularly autophagy and to a lesser extent, senescence. The linear quadratic model remains a guide for the treatment planner. The therapeutic clinical roles of apoptosis and non-apoptotic forms of cell death remain to be defined. Their relative importance will probably lie in tumor developmental history related to its type, size and stage. Radiobiological research should focus on the quantitative effects of dose and fractionation on the radiation induction of apoptotic and non-apoptotic types of cell death and the interplay among cell death pathways. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. 2012 Article Apoptosis in radiation therapy: a double-edged sword / E.K. Balcer-Kubiczek // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 277-285. — Бібліогр.: 124 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139044 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Reviews
Reviews
spellingShingle Reviews
Reviews
Balcer-Kubiczek, E.K.
Apoptosis in radiation therapy: a double-edged sword
Experimental Oncology
description Radiation therapy achieves its therapeutic effects by inducing apoptosis and non-apoptotic cell death. The aim of this focused review is to highlight the aspects of the cell death pathways most relevant to conventional fractionated radiation therapy. I review reports on how our current understanding of the molecular mechanisms of cell death may enable us to revise the four radiobiological principles (reoxygenation, repair of sublethal damage, redistribution of cells in the cell cycle, and repopulation of surviving cells) for radiation treatment with fractionated dose delivery. Apoptosis and non-apoptotic forms of cell death are not represented in the linear quadratic model, which is clinically used to calculate the effects of different total doses, dose per fraction and fraction number on reproductive cell death, a mode of cell death associated with lethal chromosome aberrations. Examples are provided to justify or not a reassessment of the role of apoptosis and non-apoptotic cell death in radiosensitivity, tumor cell proliferation and tumor microenvironment. As our understanding of apoptosis developed at the molecular level, so did our understanding of other forms of cell death, particularly autophagy and to a lesser extent, senescence. The linear quadratic model remains a guide for the treatment planner. The therapeutic clinical roles of apoptosis and non-apoptotic forms of cell death remain to be defined. Their relative importance will probably lie in tumor developmental history related to its type, size and stage. Radiobiological research should focus on the quantitative effects of dose and fractionation on the radiation induction of apoptotic and non-apoptotic types of cell death and the interplay among cell death pathways. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
format Article
author Balcer-Kubiczek, E.K.
author_facet Balcer-Kubiczek, E.K.
author_sort Balcer-Kubiczek, E.K.
title Apoptosis in radiation therapy: a double-edged sword
title_short Apoptosis in radiation therapy: a double-edged sword
title_full Apoptosis in radiation therapy: a double-edged sword
title_fullStr Apoptosis in radiation therapy: a double-edged sword
title_full_unstemmed Apoptosis in radiation therapy: a double-edged sword
title_sort apoptosis in radiation therapy: a double-edged sword
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2012
topic_facet Reviews
url http://dspace.nbuv.gov.ua/handle/123456789/139044
citation_txt Apoptosis in radiation therapy: a double-edged sword / E.K. Balcer-Kubiczek // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 277-285. — Бібліогр.: 124 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT balcerkubiczekek apoptosisinradiationtherapyadoubleedgedsword
first_indexed 2023-10-18T21:19:33Z
last_indexed 2023-10-18T21:19:33Z
_version_ 1796152513378910208