Cytometry of apoptosis. Historical perspective and new advances
Characteristic changes in cell morphology paralleled by the appearance of a multitude of molecular and biochemical markers occur during apoptosis. These changes vary depending on the cell type, mechanism of induction of apoptosis, and the time-window at which the process of apoptosis is analyzed. By...
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| Дата: | 2012 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/139051 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Cytometry of apoptosis. Historical perspective and new advances / D. Wlodkovic, J. Skommer, Z. Darzynkiewicz // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 255-262. — Бібліогр.: 78 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
irk-123456789-139051 |
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dspace |
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irk-123456789-1390512018-06-20T03:11:30Z Cytometry of apoptosis. Historical perspective and new advances Wlodkowic, D. Skommer, J. Darzynkiewicz, Z. Reviews Characteristic changes in cell morphology paralleled by the appearance of a multitude of molecular and biochemical markers occur during apoptosis. These changes vary depending on the cell type, mechanism of induction of apoptosis, and the time-window at which the process of apoptosis is analyzed. By virtue of the capability of rapid measurement of individual cells the flow- and imaging-cytometry become preferred technologies to detect, identify and record incidence of apoptosis in large cell populations. It also provided a valuable tool to investigate molecular mechanisms in field of necrobiology. This review outlines the progress in development of the most commonly used cytometric methods probing cells death based on analysis of fragmentation of DNA, activation of caspases, analysis of mitochondrial potential, alterations in plasma membrane structure and other features that characterize programmed cell death. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later” 2012 Article Cytometry of apoptosis. Historical perspective and new advances / D. Wlodkovic, J. Skommer, Z. Darzynkiewicz // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 255-262. — Бібліогр.: 78 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139051 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Wlodkowic, D. Skommer, J. Darzynkiewicz, Z. Cytometry of apoptosis. Historical perspective and new advances Experimental Oncology |
| description |
Characteristic changes in cell morphology paralleled by the appearance of a multitude of molecular and biochemical markers occur during apoptosis. These changes vary depending on the cell type, mechanism of induction of apoptosis, and the time-window at which the process of apoptosis is analyzed. By virtue of the capability of rapid measurement of individual cells the flow- and imaging-cytometry become preferred technologies to detect, identify and record incidence of apoptosis in large cell populations. It also provided a valuable tool to investigate molecular mechanisms in field of necrobiology. This review outlines the progress in development of the most commonly used cytometric methods probing cells death based on analysis of fragmentation of DNA, activation of caspases, analysis of mitochondrial potential, alterations in plasma membrane structure and other features that characterize programmed cell death. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later” |
| format |
Article |
| author |
Wlodkowic, D. Skommer, J. Darzynkiewicz, Z. |
| author_facet |
Wlodkowic, D. Skommer, J. Darzynkiewicz, Z. |
| author_sort |
Wlodkowic, D. |
| title |
Cytometry of apoptosis. Historical perspective and new advances |
| title_short |
Cytometry of apoptosis. Historical perspective and new advances |
| title_full |
Cytometry of apoptosis. Historical perspective and new advances |
| title_fullStr |
Cytometry of apoptosis. Historical perspective and new advances |
| title_full_unstemmed |
Cytometry of apoptosis. Historical perspective and new advances |
| title_sort |
cytometry of apoptosis. historical perspective and new advances |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/139051 |
| citation_txt |
Cytometry of apoptosis. Historical perspective and new advances / D. Wlodkovic, J. Skommer, Z. Darzynkiewicz // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 255-262. — Бібліогр.: 78 назв. — англ. |
| series |
Experimental Oncology |
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AT wlodkowicd cytometryofapoptosishistoricalperspectiveandnewadvances AT skommerj cytometryofapoptosishistoricalperspectiveandnewadvances AT darzynkiewiczz cytometryofapoptosishistoricalperspectiveandnewadvances |
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2023-10-18T21:19:34Z |
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2023-10-18T21:19:34Z |
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