Splice variants in apoptotic pathway
Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term “apoptosis” was introduced by Kerr et al. in 1972; among the programmed cell dea...
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| Дата: | 2012 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/139085 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Splice variants in apoptotic pathway / K. Miura, W. Fujibuchi, M. Unno // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 212-217. — Бібліогр.: 71 назв. — англ. |
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irk-123456789-1390852018-06-20T03:11:22Z Splice variants in apoptotic pathway Miura, K. Fujibuchi, W. Unno, M. Reviews Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term “apoptosis” was introduced by Kerr et al. in 1972; among the programmed cell death, a variety of therapeutic strategies especially targeting apoptotic pathways have been investigated. Alternative precursor messenger RNA splicing, by which the process the exons of pre-mRNA are spliced in different arrangements to produce structurally and functionally distinct mRNA and proteins, is another field in progress, and it has been recognized as one of the most important mechanisms that maintains genomic and functional diversity. A variety of apoptotic genes are regulated through alternative pre-mRNA splicing as well, some of which have important functions as pro-apoptotic and anti-apoptotic factors. In this article we summarized splice variants of some of the apoptotic genes including BCL2L1, BIRC5, CFLAR, and MADD, as well as the regulatory mechanisms of alternative splicing of these genes. If the information of the apoptosis and aberrant splicing in each of malignancies is integrated, it will become possible to target proper variants for apoptosis, and the trans-elements themselves can become specific targets of cancer therapy as well. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. 2012 Article Splice variants in apoptotic pathway / K. Miura, W. Fujibuchi, M. Unno // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 212-217. — Бібліогр.: 71 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139085 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Miura, K. Fujibuchi, W. Unno, M. Splice variants in apoptotic pathway Experimental Oncology |
| description |
Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis, and deregulation of apoptotic signaling pathways contributes to oncogenesis. 40 years have passed since the term “apoptosis” was introduced by Kerr et al. in 1972; among the programmed cell death, a variety of therapeutic strategies especially targeting apoptotic pathways have been investigated. Alternative precursor messenger RNA splicing, by which the process the exons of pre-mRNA are spliced in different arrangements to produce structurally and functionally distinct mRNA and proteins, is another field in progress, and it has been recognized as one of the most important mechanisms that maintains genomic and functional diversity. A variety of apoptotic genes are regulated through alternative pre-mRNA splicing as well, some of which have important functions as pro-apoptotic and anti-apoptotic factors. In this article we summarized splice variants of some of the apoptotic genes including BCL2L1, BIRC5, CFLAR, and MADD, as well as the regulatory mechanisms of alternative splicing of these genes. If the information of the apoptosis and aberrant splicing in each of malignancies is integrated, it will become possible to target proper variants for apoptosis, and the trans-elements themselves can become specific targets of cancer therapy as well. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”. |
| format |
Article |
| author |
Miura, K. Fujibuchi, W. Unno, M. |
| author_facet |
Miura, K. Fujibuchi, W. Unno, M. |
| author_sort |
Miura, K. |
| title |
Splice variants in apoptotic pathway |
| title_short |
Splice variants in apoptotic pathway |
| title_full |
Splice variants in apoptotic pathway |
| title_fullStr |
Splice variants in apoptotic pathway |
| title_full_unstemmed |
Splice variants in apoptotic pathway |
| title_sort |
splice variants in apoptotic pathway |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/139085 |
| citation_txt |
Splice variants in apoptotic pathway / K. Miura, W. Fujibuchi, M. Unno // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 212-217. — Бібліогр.: 71 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:19:36Z |
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2023-10-18T21:19:36Z |
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