Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study
To analyze the patterns of human beta-defensin-1, 2, 4 (hBDs) expression in human lung tumors. Materials and Methods: Tissue samples of surgically resected human lung tumors (squamous cell carcinoma (SCC), n = 10; adenocarcinoma (AC), n = 10) paired with conditionally normal tissue samples were anal...
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| Дата: | 2008 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2008
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/139222 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study / T. Shestakova, E. Zhuravel, L. Bolgova, O. Alekseenko, M. Soldatkina, P. Pogrebnoy // Experimental Oncology. — 2008. — Т. 30, № 2. — С. 153–156. — Бібліогр.: 19 назв. — англ. |
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irk-123456789-1392222018-06-20T03:12:00Z Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study Shestakova, T. Zhuravel, E. Bolgova, L. Alekseenko, O. Soldatkina, M. Pogrebnoy, P. Short communications To analyze the patterns of human beta-defensin-1, 2, 4 (hBDs) expression in human lung tumors. Materials and Methods: Tissue samples of surgically resected human lung tumors (squamous cell carcinoma (SCC), n = 10; adenocarcinoma (AC), n = 10) paired with conditionally normal tissue samples were analized for expression of hBD-1, 2, 4 mRNA by semiquantitive RT-PCR. Results: In a number of studied lung cancer tissue samples, overexpression of defensin mRNA was registered: hBD-1 mRNA (50% of SCC and 60% AC), hBD-2 mRNA (60% of SCC and 50% of AC) or hBD-4 (40% of SCC and 20% AC). No correlation was detected between the levels of hBD-1, hBD-2 and hBD-4 mRNA and histological type, differentiation grade of the tumor, and the stage of the disease, as well as the content of hBD-2 peptide in blood serum of lung cancer patients. Conclusion: Human beta-defensins-1 and -2 are often up-regulated in human lung tumors. Цель: проанализировать особенности экспрессии мРНК бета-дефенсинов-1, 2, 4 (hBDs) в ткани опухоли легкого человека. Материалы и методы: с помощью метода полуколичественного RT-PCR-анализа изучали уровень экспрессии мРНК hBD-1, 2, 4 в образцах ткани хирургически удаленных опухолей легкого человека (плоскоклеточный рак — ПКР, n = 10; аденокарцинома — AК, n = 10) по сравнению с образцами условно-нормальной ткани легкого тех же пациентов. Результаты: в ряде исследованных образцов опухолей легкого выявлена повышенная экспрессия мРНК hBD-1 (50% ПКР и 60% AК), hBD-2 (60% ПКР и 50% АК) или hBD-4 (40% ПКР и 20% AК). Зависимости между уровнем экспрессии бета-дефенсинов и гистологическим типом опухоли, стадией заболевания и содержанием пептида hBD-2 в сыворотке крови больных не установлено. Выводы: в ткани опухоли легкого человека часто активирована экспрессия hBD-1 и hBD-2. 2008 Article Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study / T. Shestakova, E. Zhuravel, L. Bolgova, O. Alekseenko, M. Soldatkina, P. Pogrebnoy // Experimental Oncology. — 2008. — Т. 30, № 2. — С. 153–156. — Бібліогр.: 19 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139222 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Shestakova, T. Zhuravel, E. Bolgova, L. Alekseenko, O. Soldatkina, M. Pogrebnoy, P. Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study Experimental Oncology |
| description |
To analyze the patterns of human beta-defensin-1, 2, 4 (hBDs) expression in human lung tumors. Materials and Methods: Tissue samples of surgically resected human lung tumors (squamous cell carcinoma (SCC), n = 10; adenocarcinoma (AC), n = 10) paired with conditionally normal tissue samples were analized for expression of hBD-1, 2, 4 mRNA by semiquantitive RT-PCR. Results: In a number of studied lung cancer tissue samples, overexpression of defensin mRNA was registered: hBD-1 mRNA (50% of SCC and 60% AC), hBD-2 mRNA (60% of SCC and 50% of AC) or hBD-4 (40% of SCC and 20% AC). No correlation was detected between the levels of hBD-1, hBD-2 and hBD-4 mRNA and histological type, differentiation grade of the tumor, and the stage of the disease, as well as the content of hBD-2 peptide in blood serum of lung cancer patients. Conclusion: Human beta-defensins-1 and -2 are often up-regulated in human lung tumors. |
| format |
Article |
| author |
Shestakova, T. Zhuravel, E. Bolgova, L. Alekseenko, O. Soldatkina, M. Pogrebnoy, P. |
| author_facet |
Shestakova, T. Zhuravel, E. Bolgova, L. Alekseenko, O. Soldatkina, M. Pogrebnoy, P. |
| author_sort |
Shestakova, T. |
| title |
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study |
| title_short |
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study |
| title_full |
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study |
| title_fullStr |
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study |
| title_full_unstemmed |
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study |
| title_sort |
expression of human beta-defensins-1, 2 and 4 mrna in human lung tumor tissue: a pilot study |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2008 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/139222 |
| citation_txt |
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study / T. Shestakova, E. Zhuravel, L. Bolgova, O. Alekseenko, M. Soldatkina, P. Pogrebnoy // Experimental Oncology. — 2008. — Т. 30, № 2. — С. 153–156. — Бібліогр.: 19 назв. — англ. |
| series |
Experimental Oncology |
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