Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles
Objectives: To evaluate the ability of manganese perovskite nanoparticles (lanthanum-strontium manganite) to heat the tumor tissue in vivo under action of external alternating magnetic field. Materials and Methods: The magnetic fluid on the basis of nanoparticles of perovskite manganite was tested i...
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| Видавець: | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| Дата: | 2012 |
| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2012
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/139876 |
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| Цитувати: | Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles / L. Bubnovskaya, A. Belous, A. Solopan, A. Podoltsev, I. Kondratenko, A. Kovelskaya, T. Sergienko, S. Osinsky // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 336-339. — Бібліогр.: 14 назв. — англ. |
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irk-123456789-1398762018-06-22T03:05:09Z Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles Bubnovskaya, L. Belous, A. Solopan, A. Podoltsev, A. Kondratenko, I. Kovelskaya, A. Sergienko, T. Osinsky, S. Original contributions Objectives: To evaluate the ability of manganese perovskite nanoparticles (lanthanum-strontium manganite) to heat the tumor tissue in vivo under action of external alternating magnetic field. Materials and Methods: The magnetic fluid on the basis of nanoparticles of perovskite manganite was tested in the heating experiments using of alternating magnetic field of frequency 300 kHz and amplitude 7.7 kA/m. Guerin carcinoma was transplanted into the muscle of rat. Magnetic fluid was injected intramuscularly or intratumorally. Temperature was measured by copper-constantan thermocouple. Results: Temperature of magnetic fluid was increased by 56 °C for 10 min of alternating magnetic field action. Administration of magnetic fluid into the muscle followed by alternating magnetic field resulted in the elevation of muscle temperature by 8 °C after 30 min post injection. Temperature of the tumor injected with magnetic fluid and treated by alternating magnetic field was increased by 13.6 °C on the 30 min of combined influence. Conclusion: In vivo study with rat tissue has demonstrated that magnetic fluid of manganite perovskite injected in the tumor increases the tumor temperature under an alternating magnetic field. Obtained results emphasize that magnetic fluid of manganite perovskite can be considered as effective inducer of tumor hyperthermia. 2012 Article Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles / L. Bubnovskaya, A. Belous, A. Solopan, A. Podoltsev, I. Kondratenko, A. Kovelskaya, T. Sergienko, S. Osinsky // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 336-339. — Бібліогр.: 14 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139876 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Bubnovskaya, L. Belous, A. Solopan, A. Podoltsev, A. Kondratenko, I. Kovelskaya, A. Sergienko, T. Osinsky, S. Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles Experimental Oncology |
| description |
Objectives: To evaluate the ability of manganese perovskite nanoparticles (lanthanum-strontium manganite) to heat the tumor tissue in vivo under action of external alternating magnetic field. Materials and Methods: The magnetic fluid on the basis of nanoparticles of perovskite manganite was tested in the heating experiments using of alternating magnetic field of frequency 300 kHz and amplitude 7.7 kA/m. Guerin carcinoma was transplanted into the muscle of rat. Magnetic fluid was injected intramuscularly or intratumorally. Temperature was measured by copper-constantan thermocouple. Results: Temperature of magnetic fluid was increased by 56 °C for 10 min of alternating magnetic field action. Administration of magnetic fluid into the muscle followed by alternating magnetic field resulted in the elevation of muscle temperature by 8 °C after 30 min post injection. Temperature of the tumor injected with magnetic fluid and treated by alternating magnetic field was increased by 13.6 °C on the 30 min of combined influence. Conclusion: In vivo study with rat tissue has demonstrated that magnetic fluid of manganite perovskite injected in the tumor increases the tumor temperature under an alternating magnetic field. Obtained results emphasize that magnetic fluid of manganite perovskite can be considered as effective inducer of tumor hyperthermia. |
| format |
Article |
| author |
Bubnovskaya, L. Belous, A. Solopan, A. Podoltsev, A. Kondratenko, I. Kovelskaya, A. Sergienko, T. Osinsky, S. |
| author_facet |
Bubnovskaya, L. Belous, A. Solopan, A. Podoltsev, A. Kondratenko, I. Kovelskaya, A. Sergienko, T. Osinsky, S. |
| author_sort |
Bubnovskaya, L. |
| title |
Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles |
| title_short |
Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles |
| title_full |
Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles |
| title_fullStr |
Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles |
| title_full_unstemmed |
Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles |
| title_sort |
nanohyperthermia of malignant tumors. ii. in vivo tumor heating with manganese perovskite nanoparticles |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2012 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/139876 |
| citation_txt |
Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles / L. Bubnovskaya, A. Belous, A. Solopan, A. Podoltsev, I. Kondratenko, A. Kovelskaya, T. Sergienko, S. Osinsky // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 336-339. — Бібліогр.: 14 назв. — англ. |
| series |
Experimental Oncology |
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2023-10-18T21:20:34Z |
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2023-10-18T21:20:34Z |
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