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Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer

Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer

Aim:To assess the frequency and spectrum of chromosome aberrations and micronuclei in peripheral blood lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer during the course of neutron therapy. Materials and Methods: Samples of peripheral blood were obtained from 9...

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Main Authors: Melnikov, A.A., Vasilyev, S.A., Musabaeva, L.I., Velikaya, V.V., Gribova, O.V., Startseva, Zh.A., Urazova, L.N., Lebedev, I.N., Choynzonov, E.L.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
Series:Experimental Oncology
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Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/139878
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spelling irk-123456789-1398782018-06-22T03:04:54Z Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer Melnikov, A.A. Vasilyev, S.A. Musabaeva, L.I. Velikaya, V.V. Gribova, O.V. Startseva, Zh.A. Urazova, L.N. Lebedev, I.N. Choynzonov, E.L. Original contributions Aim:To assess the frequency and spectrum of chromosome aberrations and micronuclei in peripheral blood lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer during the course of neutron therapy. Materials and Methods: Samples of peripheral blood were obtained from 9 patients with parotid salivary gland tumors (T3N0–3M0) and 8 patients with relapse of breast cancer before, after first fraction and at the end of neutron therapy. The treatment course specified 5.5–8.4 Gy (equivalent to 23–44 Gy of photon irradiation) with 1.3–2.2 Gy per fraction for patients with parotid salivary gland tumors and 4,8–8.0 Gy (equivalent to 30–40 Gy of photon irradiation) with 1.6 Gy per fraction for patients with relapse of breast cancer. Control group established for conventional cytogenetic analysis consisted of 15 healthy persons. Assessment of chromosome aberrations frequency was performed on routinely stained metaphase plates. Lymphocytes from the same patients were analyzed by micronucleus test in combination with fluorescent in situ hybridization (FISH) using pancentromeric DNA probe. Results: Level of chromosome aberrations and micronuclei significantly increased in lymphocytes of patients from both groups during neutron therapy (P < 0.05). This increase was mainly due to chromosome-type aberrations and centromere-negative micronuclei. The prevalent types of aberrations are in agreement with theoretical mechanisms of neutron effects on cells. Conclusion: Cytogenetic effects of fast neutron therapy in lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer were observed. A positive dynamics of radiation-induced chromosomal damages formation during the course was denoted in lymphocytes of cancer patients in both groups. 2012 Article Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer / A.A. Melnikov, S.A. Vasilyev, L.I. Musabaeva, V.V. Velikaya, O.V. Gribova, Zh.A. Startseva, L.N. Urazova, I.N. Lebedev, E.L. Choynzonov // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 354-357. — Бібліогр.: 19 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139878 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Melnikov, A.A.
Vasilyev, S.A.
Musabaeva, L.I.
Velikaya, V.V.
Gribova, O.V.
Startseva, Zh.A.
Urazova, L.N.
Lebedev, I.N.
Choynzonov, E.L.
Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer
Experimental Oncology
description Aim:To assess the frequency and spectrum of chromosome aberrations and micronuclei in peripheral blood lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer during the course of neutron therapy. Materials and Methods: Samples of peripheral blood were obtained from 9 patients with parotid salivary gland tumors (T3N0–3M0) and 8 patients with relapse of breast cancer before, after first fraction and at the end of neutron therapy. The treatment course specified 5.5–8.4 Gy (equivalent to 23–44 Gy of photon irradiation) with 1.3–2.2 Gy per fraction for patients with parotid salivary gland tumors and 4,8–8.0 Gy (equivalent to 30–40 Gy of photon irradiation) with 1.6 Gy per fraction for patients with relapse of breast cancer. Control group established for conventional cytogenetic analysis consisted of 15 healthy persons. Assessment of chromosome aberrations frequency was performed on routinely stained metaphase plates. Lymphocytes from the same patients were analyzed by micronucleus test in combination with fluorescent in situ hybridization (FISH) using pancentromeric DNA probe. Results: Level of chromosome aberrations and micronuclei significantly increased in lymphocytes of patients from both groups during neutron therapy (P < 0.05). This increase was mainly due to chromosome-type aberrations and centromere-negative micronuclei. The prevalent types of aberrations are in agreement with theoretical mechanisms of neutron effects on cells. Conclusion: Cytogenetic effects of fast neutron therapy in lymphocytes of patients with parotid salivary gland tumors and relapse of breast cancer were observed. A positive dynamics of radiation-induced chromosomal damages formation during the course was denoted in lymphocytes of cancer patients in both groups.
format Article
author Melnikov, A.A.
Vasilyev, S.A.
Musabaeva, L.I.
Velikaya, V.V.
Gribova, O.V.
Startseva, Zh.A.
Urazova, L.N.
Lebedev, I.N.
Choynzonov, E.L.
author_facet Melnikov, A.A.
Vasilyev, S.A.
Musabaeva, L.I.
Velikaya, V.V.
Gribova, O.V.
Startseva, Zh.A.
Urazova, L.N.
Lebedev, I.N.
Choynzonov, E.L.
author_sort Melnikov, A.A.
title Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer
title_short Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer
title_full Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer
title_fullStr Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer
title_full_unstemmed Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer
title_sort cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2012
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/139878
citation_txt Cytogenetic effects of neutron therapy in patients with parotid gland tumors and relapse of breast cancer / A.A. Melnikov, S.A. Vasilyev, L.I. Musabaeva, V.V. Velikaya, O.V. Gribova, Zh.A. Startseva, L.N. Urazova, I.N. Lebedev, E.L. Choynzonov // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 354-357. — Бібліогр.: 19 назв. — англ.
series Experimental Oncology
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first_indexed 2023-10-18T21:20:34Z
last_indexed 2023-10-18T21:20:34Z
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