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Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells

Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells

Zinc is one of the most essential trace elements in human organism. Low blood level of zinc is often noted in acute lymphocytic leukemia (ALL). Treatment with zinc adjuvant is hypothesized to accelerate recovery from ALL, and in conjunction with chemotherapy, cure ALL. Aim: We determined the effect...

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Main Authors: Wysokinski, D., Blasiak, J., Wozniak, K.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
Series:Experimental Oncology
Subjects:
Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/139900
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spelling irk-123456789-1399002018-06-22T03:06:06Z Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells Wysokinski, D. Blasiak, J. Wozniak, K. Original contributions Zinc is one of the most essential trace elements in human organism. Low blood level of zinc is often noted in acute lymphocytic leukemia (ALL). Treatment with zinc adjuvant is hypothesized to accelerate recovery from ALL, and in conjunction with chemotherapy, cure ALL. Aim: We determined the effect of zinc on DNA damage induced by doxorubicin and idarubicin, two anthracyclines used in ALL treatment. Methods: The experiment was performed on acute lymphoblastic leukemia cell line (CCRF-CEM) and lymphocytes from peripheral blood of healthy, adult subjects. To evaluate the level of DNA damage the comet assay in the alkaline version was used. Results: We observed a significant difference in DNA damage level between normal and cancer cells in the presence of zinc. Cancer cells exhibited a significant increase of DNA damage in the presence of zinc, while in lymphocytes no such effect was observed. Conclusion: Our results suggest that zinc may protect normal cells against DNA-damaging action of anthracyclins and increase this action in cancer cells. 2012 Article Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells / D. Wysokinski, J. Blasiak, K. Wozniak // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 327-331. — Бібліогр.: 31 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139900 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Wysokinski, D.
Blasiak, J.
Wozniak, K.
Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells
Experimental Oncology
description Zinc is one of the most essential trace elements in human organism. Low blood level of zinc is often noted in acute lymphocytic leukemia (ALL). Treatment with zinc adjuvant is hypothesized to accelerate recovery from ALL, and in conjunction with chemotherapy, cure ALL. Aim: We determined the effect of zinc on DNA damage induced by doxorubicin and idarubicin, two anthracyclines used in ALL treatment. Methods: The experiment was performed on acute lymphoblastic leukemia cell line (CCRF-CEM) and lymphocytes from peripheral blood of healthy, adult subjects. To evaluate the level of DNA damage the comet assay in the alkaline version was used. Results: We observed a significant difference in DNA damage level between normal and cancer cells in the presence of zinc. Cancer cells exhibited a significant increase of DNA damage in the presence of zinc, while in lymphocytes no such effect was observed. Conclusion: Our results suggest that zinc may protect normal cells against DNA-damaging action of anthracyclins and increase this action in cancer cells.
format Article
author Wysokinski, D.
Blasiak, J.
Wozniak, K.
author_facet Wysokinski, D.
Blasiak, J.
Wozniak, K.
author_sort Wysokinski, D.
title Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells
title_short Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells
title_full Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells
title_fullStr Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells
title_full_unstemmed Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells
title_sort zinc differentially modulates dna damage induced by anthracyclines in normal and cancer cells
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2012
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/139900
citation_txt Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells / D. Wysokinski, J. Blasiak, K. Wozniak // Experimental Oncology. — 2012. — Т. 34, № 4. — С. 327-331. — Бібліогр.: 31 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT wysokinskid zincdifferentiallymodulatesdnadamageinducedbyanthracyclinesinnormalandcancercells
AT blasiakj zincdifferentiallymodulatesdnadamageinducedbyanthracyclinesinnormalandcancercells
AT wozniakk zincdifferentiallymodulatesdnadamageinducedbyanthracyclinesinnormalandcancercells
first_indexed 2023-10-18T21:20:37Z
last_indexed 2023-10-18T21:20:37Z
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