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Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma

Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma

Aim: To examine photodynamic antitumor and anti-metastatic effect of hematoporphyrin, conjugated with antibodies to VEGF in comparison with native hematoporphyrin in experiments with high metastatic, angiogenesis-independent Lewis carcinoma (LLC) and its low metastatic angiogenesis-dependent variant...

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Main Authors: Novichenko, N.L., Mamchur, A.A., Lisniak, I.O., Gamaliya, M.F.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2008
Series:Experimental Oncology
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Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/139939
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spelling irk-123456789-1399392018-06-22T03:04:50Z Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma Novichenko, N.L. Mamchur, A.A. Lisniak, I.O. Gamaliya, M.F. Original contributions Aim: To examine photodynamic antitumor and anti-metastatic effect of hematoporphyrin, conjugated with antibodies to VEGF in comparison with native hematoporphyrin in experiments with high metastatic, angiogenesis-independent Lewis carcinoma (LLC) and its low metastatic angiogenesis-dependent variant — LLC/R9. Methods: Mice with LLC or with LLC/R9 were treated by photodynamic therapy (PDT) using new photosensitizer — hematoporphyrin conjugated with antibodies to VEGF, in comparison with hematoporphyrin or aminolevulinic acid. Tumor growth indices and metastasis incidence were calculated. Results: Strong antitumor effect of PDT with new conjugate was demonstrated — delay of tumor development by 70% whereas native hematoporphyrin with the same treatment regime did not show any significant effect. Most pronounced effect of conjugate was demonstrated on the growth and metastasing of LLC/R9, which was characterized by the resistance to chemotherapeutic drugs. Slowdown of the tumor growth — up to complete regression — was detected already at the third day after PDT and, on the average was about 70% of control values. Non-conjugated hematoporphyrin under parameters chosen did not cause antitumor effect. Metastases calculation demonstrated that total metastatic volume reduced by seven times in conjugate group and by 3.5 times in hematoporphyrin group. Conclusion: Hematoporhyrin conjugate studied had high photodynamic antitumor activity. Taking into consideration substantial prevalence in clinical practice of drug-resistant tumors and angiogenesis-dependent character of metastasis process, further study and application of photosensitizers, conjugated with antibodies to VEGF, may help to improve the clinical outcomes. Цель: исследование возможного противоопухолевого и антиметастатического действия гематопорфирина, конъюгированного с антителами к VEGF, по сравнению с исходным гематопорфирином при фотодинамической терапии высокометастатической зависимой от ангиогенеза карциномы Льюис (LLC) и ее низкометастатического независимого от ангиогенеза варианта — LLC/R9. Meтоды: мышам с LLC или с LLC/R9 проводили фотодинамическую терапию (ФДТ) с новым фотосенсибилизатором — гематопорфирином, конъюгированным с антителами к VEGF, при сравнении с исходным гематопорфирином или аминолевулиновой кислотой. Учитывали размеры опухоли и развитие метастазов. Результаты: при ФДТ с конъюгатом отмечен выраженный противоопухолевый эффект — задержка роста опухоли на 60–63%, в то время как исходный гематопорфирин в выбранных условиях значимого эффекта не оказывал. Наибольшее действие конъюгат оказывал на рост и метастазирование варианта опухоли LLC/R9, характеризующегося резистентностью к химиопрепаратам. Задержку опухолевого роста — вплоть до полной регрессии — отмечали уже на 3-и сутки после ФДТ и в общем она составляла около 70% по сравнению с контролем. Подсчет количества метастазов показал, что общий объем метастазов снизился в 7 раз в группе с конъюгатом и в 3,5 раза в группе с гематопорфирином. Выводы: принимая во внимание значительное превалирование в клинической практике химиорезистентных опухолей, а также зависимого от ангиогенеза характер метастазирования, дальнейшее изучение и применение фотосенсибилизаторов, конъюгированных с антителами к VEGF, может улучшить результаты лечения. 2008 Article Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma / N.L. Novichenko, A.A. Mamchur, I.O. Lisniak, M.F. Gamaliya // Experimental Oncology. — 2008. — Т. 30, № 4. — С. 315–318. — Бібліогр.: 7 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139939 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Novichenko, N.L.
Mamchur, A.A.
Lisniak, I.O.
Gamaliya, M.F.
Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma
Experimental Oncology
description Aim: To examine photodynamic antitumor and anti-metastatic effect of hematoporphyrin, conjugated with antibodies to VEGF in comparison with native hematoporphyrin in experiments with high metastatic, angiogenesis-independent Lewis carcinoma (LLC) and its low metastatic angiogenesis-dependent variant — LLC/R9. Methods: Mice with LLC or with LLC/R9 were treated by photodynamic therapy (PDT) using new photosensitizer — hematoporphyrin conjugated with antibodies to VEGF, in comparison with hematoporphyrin or aminolevulinic acid. Tumor growth indices and metastasis incidence were calculated. Results: Strong antitumor effect of PDT with new conjugate was demonstrated — delay of tumor development by 70% whereas native hematoporphyrin with the same treatment regime did not show any significant effect. Most pronounced effect of conjugate was demonstrated on the growth and metastasing of LLC/R9, which was characterized by the resistance to chemotherapeutic drugs. Slowdown of the tumor growth — up to complete regression — was detected already at the third day after PDT and, on the average was about 70% of control values. Non-conjugated hematoporphyrin under parameters chosen did not cause antitumor effect. Metastases calculation demonstrated that total metastatic volume reduced by seven times in conjugate group and by 3.5 times in hematoporphyrin group. Conclusion: Hematoporhyrin conjugate studied had high photodynamic antitumor activity. Taking into consideration substantial prevalence in clinical practice of drug-resistant tumors and angiogenesis-dependent character of metastasis process, further study and application of photosensitizers, conjugated with antibodies to VEGF, may help to improve the clinical outcomes.
format Article
author Novichenko, N.L.
Mamchur, A.A.
Lisniak, I.O.
Gamaliya, M.F.
author_facet Novichenko, N.L.
Mamchur, A.A.
Lisniak, I.O.
Gamaliya, M.F.
author_sort Novichenko, N.L.
title Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma
title_short Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma
title_full Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma
title_fullStr Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma
title_full_unstemmed Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma
title_sort study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to vegf in mouse lewis carcinoma
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2008
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/139939
citation_txt Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma / N.L. Novichenko, A.A. Mamchur, I.O. Lisniak, M.F. Gamaliya // Experimental Oncology. — 2008. — Т. 30, № 4. — С. 315–318. — Бібліогр.: 7 назв. — англ.
series Experimental Oncology
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AT mamchuraa studyofphotodynamicefficiencyofthehematoporphyrinconjugatedwithantibodytovegfinmouselewiscarcinoma
AT lisniakio studyofphotodynamicefficiencyofthehematoporphyrinconjugatedwithantibodytovegfinmouselewiscarcinoma
AT gamaliyamf studyofphotodynamicefficiencyofthehematoporphyrinconjugatedwithantibodytovegfinmouselewiscarcinoma
first_indexed 2023-10-18T21:21:27Z
last_indexed 2023-10-18T21:21:27Z
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