miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation

• Дата: 2016
• Автори: Hashemi, M., Sanaei, S., Rezaei, M., Bahari, G., Hashemi, S.M., Mashhadi, M.A., Taheri, M., Ghavami, S.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2016
• Назва видання: Experimental Oncology
• Теми: Short communications
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/140089
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation / M. Hashemi, S. Sanaei, M. Rezaei, G. Bahari, S.M. Hashemi, M.A. Mashhadi, M. Taheri,S. Ghavami // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 57-59. — Бібліогр.: 31 назв. — англ.

Aim: MicroRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on breast cancer (BC) risk. Materials and Methods: This case-control study conducted on 160 women with BC and 192 age-matched healthy women. Genotyping of miR608 rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Our findings showed that GC genotype significantly decreased the risk of BC (odds ratio (OR) = 0.49, 95% confidence interval (CI) 0.28–0.88, p = 0.018) compared to CC genotype. Furthermore the G allele decreased the risk of BC (OR = 0.53, 95%CI 0.30–0.92, p = 0.024). No significant association was found between miR-609 genotypes and clinicopathological characteristics of BC patients (p > 0.05). Conclusion: Our findings indicate that miR-608 polymorphism might be associated with decreased risk of BC in an Iranian subpopulation. Further large-scale studies with different ethnicities are needed to verify our findings.