miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation
Aim: MicroRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608...
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| Дата: | 2016 |
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| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/140089 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation / M. Hashemi, S. Sanaei, M. Rezaei, G. Bahari, S.M. Hashemi, M.A. Mashhadi, M. Taheri,S. Ghavami // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 57-59. — Бібліогр.: 31 назв. — англ. |
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irk-123456789-1400892018-06-23T03:03:13Z miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation Hashemi, M. Sanaei, S. Rezaei, M. Bahari, G. Hashemi, S.M. Mashhadi, M.A. Taheri, M. Ghavami, S. Short communications Aim: MicroRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on breast cancer (BC) risk. Materials and Methods: This case-control study conducted on 160 women with BC and 192 age-matched healthy women. Genotyping of miR608 rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Our findings showed that GC genotype significantly decreased the risk of BC (odds ratio (OR) = 0.49, 95% confidence interval (CI) 0.28–0.88, p = 0.018) compared to CC genotype. Furthermore the G allele decreased the risk of BC (OR = 0.53, 95%CI 0.30–0.92, p = 0.024). No significant association was found between miR-609 genotypes and clinicopathological characteristics of BC patients (p > 0.05). Conclusion: Our findings indicate that miR-608 polymorphism might be associated with decreased risk of BC in an Iranian subpopulation. Further large-scale studies with different ethnicities are needed to verify our findings. 2016 Article miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation / M. Hashemi, S. Sanaei, M. Rezaei, G. Bahari, S.M. Hashemi, M.A. Mashhadi, M. Taheri,S. Ghavami // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 57-59. — Бібліогр.: 31 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/140089 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Hashemi, M. Sanaei, S. Rezaei, M. Bahari, G. Hashemi, S.M. Mashhadi, M.A. Taheri, M. Ghavami, S. miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation Experimental Oncology |
| description |
Aim: MicroRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide
polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The
present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on breast cancer (BC) risk. Materials and Methods:
This case-control study conducted on 160 women with BC and 192 age-matched healthy women. Genotyping of miR608
rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results:
Our findings showed that GC genotype significantly decreased the risk of BC (odds ratio (OR) = 0.49, 95% confidence interval
(CI) 0.28–0.88, p = 0.018) compared to CC genotype. Furthermore the G allele decreased the risk of BC (OR = 0.53,
95%CI 0.30–0.92, p = 0.024). No significant association was found between miR-609 genotypes and clinicopathological characteristics
of BC patients (p > 0.05). Conclusion: Our findings indicate that miR-608 polymorphism might be associated with decreased
risk of BC in an Iranian subpopulation. Further large-scale studies with different ethnicities are needed to verify our findings. |
| format |
Article |
| author |
Hashemi, M. Sanaei, S. Rezaei, M. Bahari, G. Hashemi, S.M. Mashhadi, M.A. Taheri, M. Ghavami, S. |
| author_facet |
Hashemi, M. Sanaei, S. Rezaei, M. Bahari, G. Hashemi, S.M. Mashhadi, M.A. Taheri, M. Ghavami, S. |
| author_sort |
Hashemi, M. |
| title |
miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_short |
miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_full |
miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_fullStr |
miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_full_unstemmed |
miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation |
| title_sort |
mir-608 rs4919510 c>g polymorphism decreased the risk of breast cancer in an iranian subpopulation |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2016 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/140089 |
| citation_txt |
miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation / M. Hashemi, S. Sanaei, M. Rezaei, G. Bahari, S.M. Hashemi, M.A. Mashhadi, M. Taheri,S. Ghavami // Experimental Oncology. — 2016 — Т. 38, № 1. — С. 57-59. — Бібліогр.: 31 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
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| first_indexed |
2023-10-18T21:22:07Z |
| last_indexed |
2023-10-18T21:22:07Z |
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