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Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients
The expression of the main effector protein kinase Akt of the PI3K signaling pathway and the activities of mTOR and p70S6K protein kinases in lymphocytes of patients with diabetes mellitus are determined at the combination treatment with insulin and hypoglycemic drugs. It is shown that the Akt exp...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Видавничий дім "Академперіодика" НАН України
2018
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| Series: | Доповіді НАН України |
| Subjects: | |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/143441 |
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| Summary: | The expression of the main effector protein kinase Akt of the PI3K signaling pathway and the activities of mTOR
and p70S6K protein kinases in lymphocytes of patients with diabetes mellitus are determined at the combination
treatment with insulin and hypoglycemic drugs. It is shown that the Akt expression is reduced in blood mononuclear
cells of patients with diabetes of the 2nd and, to a less extent, type 1. The activities of mTOR and p70S6K are
also reduced in lymphocytes of patients with type 2 diabetes. Possible mechanisms of inhibiting the expression and
activity of protein kinases are discussed. |
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