Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients
The expression of the main effector protein kinase Akt of the PI3K signaling pathway and the activities of mTOR and p70S6K protein kinases in lymphocytes of patients with diabetes mellitus are determined at the combination treatment with insulin and hypoglycemic drugs. It is shown that the Akt exp...
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| Дата: | 2018 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Видавничий дім "Академперіодика" НАН України
2018
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| Назва видання: | Доповіді НАН України |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/143441 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients / L.K. Sokolova, V.M. Pushkarev, Yu.B. Belchina, V.V. Pushkarev, T.S. Vatseba, M.D. Tronko // Доповіді Національної академії наук України. — 2018. — № 8. — С. 105-109. — Бібліогр.: 14 назв. — англ. |
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irk-123456789-1434412018-11-03T01:23:14Z Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients Sokolova, L.K. Pushkarev, V.M. Belchina, Yu.B. Pushkarev, V.V. Vatseba, T.S. Tronko, M.D. Медицина The expression of the main effector protein kinase Akt of the PI3K signaling pathway and the activities of mTOR and p70S6K protein kinases in lymphocytes of patients with diabetes mellitus are determined at the combination treatment with insulin and hypoglycemic drugs. It is shown that the Akt expression is reduced in blood mononuclear cells of patients with diabetes of the 2nd and, to a less extent, type 1. The activities of mTOR and p70S6K are also reduced in lymphocytes of patients with type 2 diabetes. Possible mechanisms of inhibiting the expression and activity of protein kinases are discussed. Визначали експресію основної ефекторної протеїнкінази сигнального шляху PI3K Akt та активність протеїнкіназ mTOR і p70S6K в лімфоцитах хворих на цукровий діабет при комбінованому лікуванні інсуліном і цукрознижувальними препаратами. Показано, що експресія Akt знижена в мононуклеарах крові хворих на діабет 2-го і, меншою мірою, 1-го типу. Активність mTOR і p70S6K також знижена в лімфоцитах хворих на діабет 2-го типу. Обговорюються можливі механізми пригнічення експресії і активності протеїнкіназ. Определяли экспрессию основной эффекторной протеинкиназы сигнального пути PI3K Akt и активность протеинкиназ mTOR и p70S6K в лимфоцитах больных сахарным диабетом при комбинированном лечении инсулином и сахароснижающими препаратами. Показано, что экспрессия Akt снижена в мононуклеарах крови больных диабетом 2-го и, в меньшей степени, 1-го типа. Активность mTOR и p70S6K также снижена в лимфоцитах больных диабетом 2-го типа. Обсуждаются возможные механизмы подавления экспрессии и активности протеинкиназ. 2018 Article Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients / L.K. Sokolova, V.M. Pushkarev, Yu.B. Belchina, V.V. Pushkarev, T.S. Vatseba, M.D. Tronko // Доповіді Національної академії наук України. — 2018. — № 8. — С. 105-109. — Бібліогр.: 14 назв. — англ. 1025-6415 DOI: doi.org/10.15407/dopovidi2018.08.105 http://dspace.nbuv.gov.ua/handle/123456789/143441 616.379008.64002:577.2 en Доповіді НАН України Видавничий дім "Академперіодика" НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Медицина Медицина |
| spellingShingle |
Медицина Медицина Sokolova, L.K. Pushkarev, V.M. Belchina, Yu.B. Pushkarev, V.V. Vatseba, T.S. Tronko, M.D. Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients Доповіді НАН України |
| description |
The expression of the main effector protein kinase Akt of the PI3K signaling pathway and the activities of mTOR
and p70S6K protein kinases in lymphocytes of patients with diabetes mellitus are determined at the combination
treatment with insulin and hypoglycemic drugs. It is shown that the Akt expression is reduced in blood mononuclear
cells of patients with diabetes of the 2nd and, to a less extent, type 1. The activities of mTOR and p70S6K are
also reduced in lymphocytes of patients with type 2 diabetes. Possible mechanisms of inhibiting the expression and
activity of protein kinases are discussed. |
| format |
Article |
| author |
Sokolova, L.K. Pushkarev, V.M. Belchina, Yu.B. Pushkarev, V.V. Vatseba, T.S. Tronko, M.D. |
| author_facet |
Sokolova, L.K. Pushkarev, V.M. Belchina, Yu.B. Pushkarev, V.V. Vatseba, T.S. Tronko, M.D. |
| author_sort |
Sokolova, L.K. |
| title |
Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients |
| title_short |
Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients |
| title_full |
Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients |
| title_fullStr |
Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients |
| title_full_unstemmed |
Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients |
| title_sort |
effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of akt, mtor, and p70s6k protein kinases in lymphocytes of diabetic patients |
| publisher |
Видавничий дім "Академперіодика" НАН України |
| publishDate |
2018 |
| topic_facet |
Медицина |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/143441 |
| citation_txt |
Effect of combined treatment with insulin, metformin, and gliclazide on the expression and activity of Akt, mTOR, and p70S6K protein kinases in lymphocytes of diabetic patients / L.K. Sokolova, V.M. Pushkarev, Yu.B. Belchina, V.V. Pushkarev, T.S. Vatseba, M.D. Tronko // Доповіді Національної академії наук України. — 2018. — № 8. — С. 105-109. — Бібліогр.: 14 назв. — англ. |
| series |
Доповіді НАН України |
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2023-05-20T17:16:59Z |
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2023-05-20T17:16:59Z |
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