The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients
Application of the multimodal enhanced recovery program (ERP) proved its effectiveness in surgical treatment of patients with colon cancer. The impact of an ERP on the long-term outcomes remains a challenge. Aim of the study: to assess the impact of an ERP on the long-term outcomes of the surgical...
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| Дата: | 2015 |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
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| Назва видання: | Онкологія |
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| Цитувати: | The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients / O.O. Kolesnik, I.I. Lisnyi, A.A. Shudrak, A.V. Lukashenko, D.E. Mahmudov, A.A. Burlaka // Онкологія. — 2015. — Т. 17, № 2. — С. 102-106. — Бібліогр.: 20 назв. — англ. |
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irk-123456789-1450242019-01-14T01:23:37Z The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients Kolesnik, O.O. Lisnyi, I.I. Shudrak, A.A. Lukashenko, A.V. Mahmudov, D.E. Burlaka, A.A. Оригинальные исследования Application of the multimodal enhanced recovery program (ERP) proved its effectiveness in surgical treatment of patients with colon cancer. The impact of an ERP on the long-term outcomes remains a challenge. Aim of the study: to assess the impact of an ERP on the long-term outcomes of the surgical treatment of colon cancer patients. Object and methods: a total of 230 patients, who underwent curative surgery for colon cancer from 2008 to 2013, were enrolled and divided into main (130 patients) and control group (100 patients). Results: no significant difference in antropometric data, tumor site, disease stage and surgery type was observed. Grade II–IV according to the Clavien — Dindo classification of surgical complications was determined in 11 (8.5%) patients of main group and in 20 (20.0%) patients of control group (р < 0.05) with postoperative mortality 0.8 and 2.0%, respectively (р < 0.05). Overall 3-year survival differed significantly: 88.4 ± 9.6% — in main and 72.2 ± 7.6% — in control group (р < 0.05) with insignificant shift in disease-free survival — 87.0 ± 7.5% and 90.0 ± 10.2%, respectively (р = 2.235). All patients who had grade II–IV complications didn’t achieve 3-year survival, with the median of 28.7 and 26.2 months (р = 1.954). Conclusion: ERP application leads to the improvement of overall survival by means of reduction of grade II–IV Clavien — Dindo complications. Применение мультимодальной программы быстрого восстановления (ПБВ) продемонстрировало свою эффективность в отношении непосредственных результатов хирургического лечения больных раком ободочной кишки. На сегодня влияние ПБВ на отдаленные результаты терапии остается недостаточно изученным. Цель: оценить влияние ПБВ на отдаленные результаты хирургического лечения больных раком ободочной кишки. Объект и методы: включены 230 пациентов, которым в период с 2008 по 2013 г. проводили хирургическое лечение по поводу рака ободочной кишки. В основную группу (хирургическое лечение по ПБВ) включено 130, в группу сравнения (стандартная тактика) — 100 больных. Результаты: значимых межгрупповых различий по антропометрическим данным, локализации опухоли, стадии заболевания и объему оперативного вмешательства не отмечено. Среди пациентов основной группы послеоперационные осложнения II–IV класса по классификации Clavien — Dindo зарегистрированы в 11 (8,5%), а контрольной группы — в 20 (20,0%) случаях (р < 0,05). Послеоперационная летальность составила 0,8 и 2,0% соответственно (р < 0,05). Период наблюдения — 37,4 ± 4,7 мес. Общая 3-летняя выживаемость имела достоверное различие: 88,4 ± 9,6% — в основной и 72,2 ± 7,6% — в контрольной группе (р < 0,05). Общая 3-летняя безрецидивная выживаемость составила 87,0 ± 7,5 и 90,0 ± 10,2% для основной и контрольной группы соответственно (р = 2,235). У пациентов обеих групп, у которых возникли послеоперационные осложнения II–IV класса, 3-летняя выживаемость не достигнута. Медиана — 28,7 и 26,2 мес для основной и контрольной группы соответственно (р = 1,954). Выводы: применяемая ПБВ влияет на отдаленные результаты лечения за счет уменьшения количества послеоперационных осложнений II–IV класса. 2015 Article The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients / O.O. Kolesnik, I.I. Lisnyi, A.A. Shudrak, A.V. Lukashenko, D.E. Mahmudov, A.A. Burlaka // Онкологія. — 2015. — Т. 17, № 2. — С. 102-106. — Бібліогр.: 20 назв. — англ. 1562-1774 http://dspace.nbuv.gov.ua/handle/123456789/145024 en Онкологія Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Оригинальные исследования Оригинальные исследования |
| spellingShingle |
Оригинальные исследования Оригинальные исследования Kolesnik, O.O. Lisnyi, I.I. Shudrak, A.A. Lukashenko, A.V. Mahmudov, D.E. Burlaka, A.A. The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients Онкологія |
| description |
Application of the multimodal enhanced recovery program (ERP) proved its effectiveness in surgical treatment of patients with colon cancer. The impact of an ERP
on the long-term outcomes remains a challenge. Aim of the study: to assess the impact of an ERP on the long-term outcomes of the surgical treatment of colon cancer patients. Object and methods: a total of 230 patients, who underwent curative
surgery for colon cancer from 2008 to 2013, were enrolled and divided into main
(130 patients) and control group (100 patients). Results: no significant difference
in antropometric data, tumor site, disease stage and surgery type was observed.
Grade II–IV according to the Clavien — Dindo classification of surgical complications was determined in 11 (8.5%) patients of main group and in 20 (20.0%)
patients of control group (р < 0.05) with postoperative mortality 0.8 and 2.0%, respectively (р < 0.05). Overall 3-year survival differed significantly: 88.4 ± 9.6% —
in main and 72.2 ± 7.6% — in control group (р < 0.05) with insignificant shift in
disease-free survival — 87.0 ± 7.5% and 90.0 ± 10.2%, respectively (р = 2.235).
All patients who had grade II–IV complications didn’t achieve 3-year survival,
with the median of 28.7 and 26.2 months (р = 1.954). Conclusion: ERP application leads to the improvement of overall survival by means of reduction of grade
II–IV Clavien — Dindo complications. |
| format |
Article |
| author |
Kolesnik, O.O. Lisnyi, I.I. Shudrak, A.A. Lukashenko, A.V. Mahmudov, D.E. Burlaka, A.A. |
| author_facet |
Kolesnik, O.O. Lisnyi, I.I. Shudrak, A.A. Lukashenko, A.V. Mahmudov, D.E. Burlaka, A.A. |
| author_sort |
Kolesnik, O.O. |
| title |
The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients |
| title_short |
The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients |
| title_full |
The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients |
| title_fullStr |
The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients |
| title_full_unstemmed |
The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients |
| title_sort |
impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2015 |
| topic_facet |
Оригинальные исследования |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145024 |
| citation_txt |
The impact of postoperative complications and implication of a multimodal enhanced recovery programme on long-term outcomes of surgical treatment of colon cancer patients / O.O. Kolesnik, I.I. Lisnyi, A.A. Shudrak, A.V. Lukashenko, D.E. Mahmudov, A.A. Burlaka // Онкологія. — 2015. — Т. 17, № 2. — С. 102-106. — Бібліогр.: 20 назв. — англ. |
| series |
Онкологія |
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