Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastroint...
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| Дата: | 2013 |
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| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145211 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development / A. Sultanova, M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 93-96. — Бібліогр.: 18 назв. — англ. |
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irk-123456789-1452112019-01-20T01:23:38Z Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. Original contributions Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastrointestinal cancer. Methods: Sixty five patients with gastrointestinal cancer before surgery and without any treatment were enrolled in this study and divided into two groups depending on lymphocytes’ count: I group (n = 35) — lymphocytes > 1400x10⁶ /L and II group (n = 30) — lymphocytes < 1400x10⁶ /L. Nested polymerase chain reaction was used to detect latent and active stage of persistent human herpesvirus-6 and -7 infection, laser flow cytometry with monoclonal antibodies — to determine immunological parameters. Results: Activation of herpesvirus-6 and -7 was more frequently observed in the patients’ group with lymphopenia (HHV-6 1/1 (100%), HHV-7 4/8 (50%) and HHV-6 + HHV-7 6/9 (66%); p < 0.05). Cellular immune parameters were analysed in immunocompromised II group’s patients dependently on beta-herpevirus infection. Although number of leukocytes was higher in patients with active HHV-6/-7 infection (p = 0.01), number of lymphocytes CD3⁺, CD4⁺, CD8⁺ and CD38⁺ in patients with active HHV-6/-7 infection tended to decrease (p < 0.0001, P = 0.0002, p = 0.0001 and p < 0.0001, respectively). However, number of CD19+ had tendency to increase (p = 0.03). Conclusion: Activation of herpesvirus-6 and -7 may lead to decrease of lymphocytes total count and develop immunosuppression in patients with gastrointestinal cancer. Key Words: beta-herpesvirus-6, beta-herpesvirus-7, gastrointestinal cancer. 2013 Article Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development / A. Sultanova, M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 93-96. — Бібліогр.: 18 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145211 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development Experimental Oncology |
| description |
Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastrointestinal cancer. Methods: Sixty five patients with gastrointestinal cancer before surgery and without any treatment were enrolled in this study and divided into two groups depending on lymphocytes’ count: I group (n = 35) — lymphocytes > 1400x10⁶ /L and II group (n = 30) — lymphocytes < 1400x10⁶ /L. Nested polymerase chain reaction was used to detect latent and active stage of persistent human herpesvirus-6 and -7 infection, laser flow cytometry with monoclonal antibodies — to determine immunological parameters. Results: Activation of herpesvirus-6 and -7 was more frequently observed in the patients’ group with lymphopenia (HHV-6 1/1 (100%), HHV-7 4/8 (50%) and HHV-6 + HHV-7 6/9 (66%); p < 0.05). Cellular immune parameters were analysed in immunocompromised II group’s patients dependently on beta-herpevirus infection. Although number of leukocytes was higher in patients with active HHV-6/-7 infection (p = 0.01), number of lymphocytes CD3⁺, CD4⁺, CD8⁺ and CD38⁺ in patients with active HHV-6/-7 infection tended to decrease (p < 0.0001, P = 0.0002, p = 0.0001 and p < 0.0001, respectively). However, number of CD19+ had tendency to increase (p = 0.03). Conclusion: Activation of herpesvirus-6 and -7 may lead to decrease of lymphocytes total count and develop immunosuppression in patients with gastrointestinal cancer. Key Words: beta-herpesvirus-6, beta-herpesvirus-7, gastrointestinal cancer. |
| format |
Article |
| author |
Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. |
| author_facet |
Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. |
| author_sort |
Sultanova A. |
| title |
Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_short |
Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_full |
Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_fullStr |
Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_full_unstemmed |
Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| title_sort |
possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2013 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145211 |
| citation_txt |
Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development / A. Sultanova, M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 93-96. — Бібліогр.: 18 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
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2023-05-20T17:21:31Z |
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2023-05-20T17:21:31Z |
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