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Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development

Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development

Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastroint...

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Main Authors: Sultanova A., Chistjakovs M., Chapenko S., Donina S., Murovska M.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
Series:Experimental Oncology
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Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/145211
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spelling irk-123456789-1452112019-01-20T01:23:38Z Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development Sultanova A. Chistjakovs M. Chapenko S. Donina S. Murovska M. Original contributions Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastrointestinal cancer. Methods: Sixty five patients with gastrointestinal cancer before surgery and without any treatment were enrolled in this study and divided into two groups depending on lymphocytes’ count: I group (n = 35) — lymphocytes > 1400x10⁶ /L and II group (n = 30) — lymphocytes < 1400x10⁶ /L. Nested polymerase chain reaction was used to detect latent and active stage of persistent human herpesvirus-6 and -7 infection, laser flow cytometry with monoclonal antibodies — to determine immunological parameters. Results: Activation of herpesvirus-6 and -7 was more frequently observed in the patients’ group with lymphopenia (HHV-6 1/1 (100%), HHV-7 4/8 (50%) and HHV-6 + HHV-7 6/9 (66%); p < 0.05). Cellular immune parameters were analysed in immunocompromised II group’s patients dependently on beta-herpevirus infection. Although number of leukocytes was higher in patients with active HHV-6/-7 infection (p = 0.01), number of lymphocytes CD3⁺, CD4⁺, CD8⁺ and CD38⁺ in patients with active HHV-6/-7 infection tended to decrease (p < 0.0001, P = 0.0002, p = 0.0001 and p < 0.0001, respectively). However, number of CD19+ had tendency to increase (p = 0.03). Conclusion: Activation of herpesvirus-6 and -7 may lead to decrease of lymphocytes total count and develop immunosuppression in patients with gastrointestinal cancer. Key Words: beta-herpesvirus-6, beta-herpesvirus-7, gastrointestinal cancer. 2013 Article Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development / A. Sultanova, M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 93-96. — Бібліогр.: 18 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145211 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Sultanova A.
Chistjakovs M.
Chapenko S.
Donina S.
Murovska M.
Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
Experimental Oncology
description Aim: The high incidence of gastrointestinal cancer combined with high mortality from the disease if diagnosed at a late stage, signifies the need for better diagnostic, prognostic and predictive tools. Human beta-herpesviruses have been suggested as possible cofactors in the development of gastrointestinal cancer. Methods: Sixty five patients with gastrointestinal cancer before surgery and without any treatment were enrolled in this study and divided into two groups depending on lymphocytes’ count: I group (n = 35) — lymphocytes > 1400x10⁶ /L and II group (n = 30) — lymphocytes < 1400x10⁶ /L. Nested polymerase chain reaction was used to detect latent and active stage of persistent human herpesvirus-6 and -7 infection, laser flow cytometry with monoclonal antibodies — to determine immunological parameters. Results: Activation of herpesvirus-6 and -7 was more frequently observed in the patients’ group with lymphopenia (HHV-6 1/1 (100%), HHV-7 4/8 (50%) and HHV-6 + HHV-7 6/9 (66%); p < 0.05). Cellular immune parameters were analysed in immunocompromised II group’s patients dependently on beta-herpevirus infection. Although number of leukocytes was higher in patients with active HHV-6/-7 infection (p = 0.01), number of lymphocytes CD3⁺, CD4⁺, CD8⁺ and CD38⁺ in patients with active HHV-6/-7 infection tended to decrease (p < 0.0001, P = 0.0002, p = 0.0001 and p < 0.0001, respectively). However, number of CD19+ had tendency to increase (p = 0.03). Conclusion: Activation of herpesvirus-6 and -7 may lead to decrease of lymphocytes total count and develop immunosuppression in patients with gastrointestinal cancer. Key Words: beta-herpesvirus-6, beta-herpesvirus-7, gastrointestinal cancer.
format Article
author Sultanova A.
Chistjakovs M.
Chapenko S.
Donina S.
Murovska M.
author_facet Sultanova A.
Chistjakovs M.
Chapenko S.
Donina S.
Murovska M.
author_sort Sultanova A.
title Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
title_short Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
title_full Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
title_fullStr Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
title_full_unstemmed Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
title_sort possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2013
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145211
citation_txt Possible interference of human beta-herpesviruses-6 and -7 in gastrointestinal cancer development / A. Sultanova, M. Chistjakovs, S. Chapenko, S. Donina, M. Murovska // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 93-96. — Бібліогр.: 18 назв. — англ.
series Experimental Oncology
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AT chapenkos possibleinterferenceofhumanbetaherpesviruses6and7ingastrointestinalcancerdevelopment
AT doninas possibleinterferenceofhumanbetaherpesviruses6and7ingastrointestinalcancerdevelopment
AT murovskam possibleinterferenceofhumanbetaherpesviruses6and7ingastrointestinalcancerdevelopment
first_indexed 2023-05-20T17:21:31Z
last_indexed 2023-05-20T17:21:31Z
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