Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
Aim - in the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated. Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and ra...
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| Дата: | 2013 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145212 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment / D. Subramanyam, K.C.V. Subbaiah, W. Rajendra, V. Lokanatha // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 97-100. — Бібліогр.: 30 назв. — англ. |
Репозитарії
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irk-123456789-1452122019-01-20T01:23:40Z Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment Subramanyam D. Subbaiah, K.C.V. Rajendra W. Lokanatha V. Original contributions Aim - in the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated. Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and radiotherapy respectively. Plasma Se, Zn, Cu and some enzymatic antioxidants activities were estimated in serum before and after the treatment. The decreased levels of serum trace elements, glutathione peroxidase activity and total antioxidant capacity, and increased malondialdehyde, glutathion reductase was observed in cervical cancer patients when compared to healthy controls. The increased concentration of serum Se, Zn was observed in patients treated with chemotherapy. Simultaneously there was a significant (P << 0,001) increase in glutathione peroxidase and total antioxidant capacity, and significant decrease (P << 0,05) in malondialdehyde and glutathion reductase levels in the serum of patients treated with chemotherapy compared to the patients treated with radiotherapy. Key Words: cervical cancer, free radicals, glutathione peroxidase, selenium, chemotherapy, radiotherapy. 2013 Article Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment / D. Subramanyam, K.C.V. Subbaiah, W. Rajendra, V. Lokanatha // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 97-100. — Бібліогр.: 30 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145212 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Subramanyam D. Subbaiah, K.C.V. Rajendra W. Lokanatha V. Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment Experimental Oncology |
| description |
Aim - in the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated. Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and radiotherapy respectively. Plasma Se, Zn, Cu and some enzymatic antioxidants activities were estimated in serum before and after the treatment. The decreased levels of serum trace elements, glutathione peroxidase activity and total antioxidant capacity, and increased malondialdehyde, glutathion reductase was observed in cervical cancer patients when compared to healthy controls. The increased concentration of serum Se, Zn was observed in patients treated with chemotherapy. Simultaneously there was a significant (P << 0,001) increase in glutathione peroxidase and total antioxidant capacity, and significant decrease (P << 0,05) in malondialdehyde and glutathion reductase levels in the serum of patients treated with chemotherapy compared to the patients treated with radiotherapy. Key Words: cervical cancer, free radicals, glutathione peroxidase, selenium, chemotherapy, radiotherapy. |
| format |
Article |
| author |
Subramanyam D. Subbaiah, K.C.V. Rajendra W. Lokanatha V. |
| author_facet |
Subramanyam D. Subbaiah, K.C.V. Rajendra W. Lokanatha V. |
| author_sort |
Subramanyam D. |
| title |
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment |
| title_short |
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment |
| title_full |
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment |
| title_fullStr |
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment |
| title_full_unstemmed |
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment |
| title_sort |
serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2013 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145212 |
| citation_txt |
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment / D. Subramanyam, K.C.V. Subbaiah, W. Rajendra, V. Lokanatha // Experimental Oncology. — 2013. — Т. 35, № 2. — С. 97-100. — Бібліогр.: 30 назв. — англ. |
| series |
Experimental Oncology |
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2023-05-20T17:21:32Z |
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2023-05-20T17:21:32Z |
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