Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis

Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis

Aim: To study the adhesion molecules CD44 and E-cadherin expression in serous ovarian cancer (0C) and their relationship with clinicopathological peculiarities of tumor process and prognosis. Materials and Methods: The studywas performed on QC samples from 72 patients with serous DC of stages I-III....

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Бібліографічні деталі
Дата:2013
Автори: Ryabtseva, O.D., Lukianova, N.Yu., Shmurakov, Yu.A., Polishchuk, L.Z., Antipova, S.V.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/145240
Теги: Додати тег
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis / O.D. Ryabtseva, N.Yu. Lukianova, Yu.A. Shmurakov, L.Z. Polishchuk, S.V. Antipova // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 211-218. — Бібліогр.: 50 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-145240
record_format dspace
spelling irk-123456789-1452402019-01-20T01:23:23Z Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis Ryabtseva, O.D. Lukianova, N.Yu. Shmurakov, Yu.A. Polishchuk, L.Z. Antipova, S.V. Original contributions Aim: To study the adhesion molecules CD44 and E-cadherin expression in serous ovarian cancer (0C) and their relationship with clinicopathological peculiarities of tumor process and prognosis. Materials and Methods: The studywas performed on QC samples from 72 patients with serous DC of stages I-III. Expression of CD44 and E-cadherin in tumor samples was evaluated with the use ofimmunohistochemical analysis. Results: Immunohistochemical analysis has revealed that in 58.3% of 0C patients CD44 expres- sion was detected in more than 10% of cells with average level of 30.0+-5.6%. E-cadherin expressionwas present in 47.2% of tumors, and 12.2+-3.6% cells were immunopositive. CD44 and E-cadherin expression depends on degree of cytomorphological malig- nancy and cell differentiation. A reverse correlation between CD44 and E-cadherin expression in primary serous 0C (r=-0.38, p<0.05) has been found. Increased CD44 expression (mean index) was not observed in peritoneal metastases compared to primary tumors, but analysis of individual indexes showed increase of CD44 expression in 46.6% 0C patients with metastases. The dependence between overall survival of 0C patients and the molecular phenotype of tumor cells, in particular, poor prognosis for CC patients with CD44(+)/E-cadherin(-) and CD44(+)/budding(+) tumor cells phenotype, has been revealed. Conclusion: The results of morphological and immunohistochemical analysis has shown the incnease of adhesive features of serous ovarian cancer cells what may be significant for estimation of ovarian cancer aggressiveness and development of metastatic process. Key Words: serous ovarian cancer, CD44, E-cadherin, immunohistochemical analysis, morphology, budding, malignancy, prognosis. 2013 Article Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis / O.D. Ryabtseva, N.Yu. Lukianova, Yu.A. Shmurakov, L.Z. Polishchuk, S.V. Antipova // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 211-218. — Бібліогр.: 50 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145240 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Ryabtseva, O.D.
Lukianova, N.Yu.
Shmurakov, Yu.A.
Polishchuk, L.Z.
Antipova, S.V.
Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis
Experimental Oncology
description Aim: To study the adhesion molecules CD44 and E-cadherin expression in serous ovarian cancer (0C) and their relationship with clinicopathological peculiarities of tumor process and prognosis. Materials and Methods: The studywas performed on QC samples from 72 patients with serous DC of stages I-III. Expression of CD44 and E-cadherin in tumor samples was evaluated with the use ofimmunohistochemical analysis. Results: Immunohistochemical analysis has revealed that in 58.3% of 0C patients CD44 expres- sion was detected in more than 10% of cells with average level of 30.0+-5.6%. E-cadherin expressionwas present in 47.2% of tumors, and 12.2+-3.6% cells were immunopositive. CD44 and E-cadherin expression depends on degree of cytomorphological malig- nancy and cell differentiation. A reverse correlation between CD44 and E-cadherin expression in primary serous 0C (r=-0.38, p<0.05) has been found. Increased CD44 expression (mean index) was not observed in peritoneal metastases compared to primary tumors, but analysis of individual indexes showed increase of CD44 expression in 46.6% 0C patients with metastases. The dependence between overall survival of 0C patients and the molecular phenotype of tumor cells, in particular, poor prognosis for CC patients with CD44(+)/E-cadherin(-) and CD44(+)/budding(+) tumor cells phenotype, has been revealed. Conclusion: The results of morphological and immunohistochemical analysis has shown the incnease of adhesive features of serous ovarian cancer cells what may be significant for estimation of ovarian cancer aggressiveness and development of metastatic process. Key Words: serous ovarian cancer, CD44, E-cadherin, immunohistochemical analysis, morphology, budding, malignancy, prognosis.
format Article
author Ryabtseva, O.D.
Lukianova, N.Yu.
Shmurakov, Yu.A.
Polishchuk, L.Z.
Antipova, S.V.
author_facet Ryabtseva, O.D.
Lukianova, N.Yu.
Shmurakov, Yu.A.
Polishchuk, L.Z.
Antipova, S.V.
author_sort Ryabtseva, O.D.
title Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis
title_short Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis
title_full Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis
title_fullStr Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis
title_full_unstemmed Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis
title_sort significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2013
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145240
citation_txt Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis / O.D. Ryabtseva, N.Yu. Lukianova, Yu.A. Shmurakov, L.Z. Polishchuk, S.V. Antipova // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 211-218. — Бібліогр.: 50 назв. — англ.
series Experimental Oncology
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AT polishchuklz significanceofadhesionmoleculesexpressionforestimationofserousovariancancerprognosis
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first_indexed 2023-05-20T17:21:37Z
last_indexed 2023-05-20T17:21:37Z
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