Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women
Aim: DNA repair genetic polymorphisms may affect cancer susceptibility as genetic variations in DNA repair genes may influence DNA repair capacity. In the present study, the association of polymorphic forms of DNA repair gene, DNA ligase I (LIGI) was examined with the risk of cervical cancer in case...
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| Дата: | 2013 |
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| Автор: | |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145242 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women / S. Kaur // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 226-228. — Бібліогр.: 21 назв. — англ. |
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irk-123456789-1452422019-01-20T01:23:35Z Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women Kaur, S. Short communications Aim: DNA repair genetic polymorphisms may affect cancer susceptibility as genetic variations in DNA repair genes may influence DNA repair capacity. In the present study, the association of polymorphic forms of DNA repair gene, DNA ligase I (LIGI) was examined with the risk of cervical cancer in case of North Indian women. Materials and Methods: Polymorphism was determined by polymerase chain reaction — restriction fragment length polymorphism (PCR-RFLP) method and risk of cervical cancer was evaluated by calculating odds ratios (ORs) and 95% confidence interval (CI) using a multivariate logistic regression analysis. Results: No association was found between variant forms (AC, AA) of LIGI gene and risk of cervical cancer (OR — 0.8, 95% CI 0.46–1.53 and OR — 1.0, 95% CI 0.51–2.06, respectively). However, increased but statistically non-significant risk of adenocarcinoma was observed for cervical cancer patients having AC (OR — 4.6, 95% CI 0.62–33.82) and AA (OR — 5.0, 95% CI 0.63–39.58) genotypes. Conclusion: It can thus be concluded that there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women. Further investigations in larger studies need to be carried out for more analysis. 2013 Article Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women / S. Kaur // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 226-228. — Бібліогр.: 21 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145242 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Kaur, S. Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women Experimental Oncology |
| description |
Aim: DNA repair genetic polymorphisms may affect cancer susceptibility as genetic variations in DNA repair genes may influence DNA repair capacity. In the present study, the association of polymorphic forms of DNA repair gene, DNA ligase I (LIGI) was examined with the risk of cervical cancer in case of North Indian women. Materials and Methods: Polymorphism was determined by polymerase chain reaction — restriction fragment length polymorphism (PCR-RFLP) method and risk of cervical cancer was evaluated by calculating odds ratios (ORs) and 95% confidence interval (CI) using a multivariate logistic regression analysis. Results: No association was found between variant forms (AC, AA) of LIGI gene and risk of cervical cancer (OR — 0.8, 95% CI 0.46–1.53 and OR — 1.0, 95% CI 0.51–2.06, respectively). However, increased but statistically non-significant risk of adenocarcinoma was observed for cervical cancer patients having AC (OR — 4.6, 95% CI 0.62–33.82) and AA (OR — 5.0, 95% CI 0.63–39.58) genotypes. Conclusion: It can thus be concluded that there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women. Further investigations in larger studies need to be carried out for more analysis. |
| format |
Article |
| author |
Kaur, S. |
| author_facet |
Kaur, S. |
| author_sort |
Kaur, S. |
| title |
Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women |
| title_short |
Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women |
| title_full |
Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women |
| title_fullStr |
Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women |
| title_full_unstemmed |
Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women |
| title_sort |
human dna ligase i (ligi) gene and risk of cervical cancer in north indian women |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2013 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145242 |
| citation_txt |
Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women / S. Kaur // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 226-228. — Бібліогр.: 21 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
AT kaurs humandnaligaseiligigeneandriskofcervicalcancerinnorthindianwomen |
| first_indexed |
2023-05-20T17:21:37Z |
| last_indexed |
2023-05-20T17:21:37Z |
| _version_ |
1796153118251024384 |