2025-02-22T16:55:04-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: Query fl=%2A&wt=json&json.nl=arrarr&q=id%3A%22irk-123456789-145287%22&qt=morelikethis&rows=5
2025-02-22T16:55:04-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: => GET http://localhost:8983/solr/biblio/select?fl=%2A&wt=json&json.nl=arrarr&q=id%3A%22irk-123456789-145287%22&qt=morelikethis&rows=5
2025-02-22T16:55:04-05:00 DEBUG: VuFindSearch\Backend\Solr\Connector: <= 200 OK
2025-02-22T16:55:04-05:00 DEBUG: Deserialized SOLR response
Markers of epithelial-mesenchymal transition in renal cell carcinoma

Markers of epithelial-mesenchymal transition in renal cell carcinoma

Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a...

Full description

Saved in:
Bibliographic Details
Main Authors: Dumanskiy, Y.V., Kudriashov, A.G., Vasilenko, I.V., Kondratyuk, R.B., Gulkov, Y.K., Chystiakov, R.S.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
Series:Experimental Oncology
Subjects:
Arrticles not related to special issue topics
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/145287
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a long-term survival group (17 - 24 months). EMT markers expression was assessed by immunohistochemical methods. It was determined that the rate of spindle-cell EMT was 96,4 % in a short-term survival group and 42,1 % in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3 - 4 occurred in 100 % of cases in a short-term survival group versus 68,4 % in a longterm survival group. Conclusion: the rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia. Key Words: renal cell carcinoma, epithelial-mesenchymal transition, the degree of Furhman’s nuclear atypia.

Similar Items