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Markers of epithelial-mesenchymal transition in renal cell carcinoma

Markers of epithelial-mesenchymal transition in renal cell carcinoma

Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a...

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Main Authors: Dumanskiy, Y.V., Kudriashov, A.G., Vasilenko, I.V., Kondratyuk, R.B., Gulkov, Y.K., Chystiakov, R.S.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
Series:Experimental Oncology
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Arrticles not related to special issue topics
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/145287
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spelling irk-123456789-1452872020-12-08T15:26:21Z Markers of epithelial-mesenchymal transition in renal cell carcinoma Dumanskiy, Y.V. Kudriashov, A.G. Vasilenko, I.V. Kondratyuk, R.B. Gulkov, Y.K. Chystiakov, R.S. Arrticles not related to special issue topics Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a long-term survival group (17 - 24 months). EMT markers expression was assessed by immunohistochemical methods. It was determined that the rate of spindle-cell EMT was 96,4 % in a short-term survival group and 42,1 % in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3 - 4 occurred in 100 % of cases in a short-term survival group versus 68,4 % in a longterm survival group. Conclusion: the rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia. Key Words: renal cell carcinoma, epithelial-mesenchymal transition, the degree of Furhman’s nuclear atypia. 2013 Article Markers of epithelial-mesenchymal transition in renal cell carcinoma / Y.V. Dumanskiy, A.G. Kudriashov, I.V. Vasilenko, R.B. Kondratyuk, Y.K. Gulkov, R.S. Сhystiakov // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 325-327. — Бібліогр.: 14 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145287 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Arrticles not related to special issue topics
Arrticles not related to special issue topics
spellingShingle Arrticles not related to special issue topics
Arrticles not related to special issue topics
Dumanskiy, Y.V.
Kudriashov, A.G.
Vasilenko, I.V.
Kondratyuk, R.B.
Gulkov, Y.K.
Chystiakov, R.S.
Markers of epithelial-mesenchymal transition in renal cell carcinoma
Experimental Oncology
description Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a long-term survival group (17 - 24 months). EMT markers expression was assessed by immunohistochemical methods. It was determined that the rate of spindle-cell EMT was 96,4 % in a short-term survival group and 42,1 % in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3 - 4 occurred in 100 % of cases in a short-term survival group versus 68,4 % in a longterm survival group. Conclusion: the rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia. Key Words: renal cell carcinoma, epithelial-mesenchymal transition, the degree of Furhman’s nuclear atypia.
format Article
author Dumanskiy, Y.V.
Kudriashov, A.G.
Vasilenko, I.V.
Kondratyuk, R.B.
Gulkov, Y.K.
Chystiakov, R.S.
author_facet Dumanskiy, Y.V.
Kudriashov, A.G.
Vasilenko, I.V.
Kondratyuk, R.B.
Gulkov, Y.K.
Chystiakov, R.S.
author_sort Dumanskiy, Y.V.
title Markers of epithelial-mesenchymal transition in renal cell carcinoma
title_short Markers of epithelial-mesenchymal transition in renal cell carcinoma
title_full Markers of epithelial-mesenchymal transition in renal cell carcinoma
title_fullStr Markers of epithelial-mesenchymal transition in renal cell carcinoma
title_full_unstemmed Markers of epithelial-mesenchymal transition in renal cell carcinoma
title_sort markers of epithelial-mesenchymal transition in renal cell carcinoma
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2013
topic_facet Arrticles not related to special issue topics
url http://dspace.nbuv.gov.ua/handle/123456789/145287
citation_txt Markers of epithelial-mesenchymal transition in renal cell carcinoma / Y.V. Dumanskiy, A.G. Kudriashov, I.V. Vasilenko, R.B. Kondratyuk, Y.K. Gulkov, R.S. Сhystiakov // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 325-327. — Бібліогр.: 14 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT dumanskiyyv markersofepithelialmesenchymaltransitioninrenalcellcarcinoma
AT kudriashovag markersofepithelialmesenchymaltransitioninrenalcellcarcinoma
AT vasilenkoiv markersofepithelialmesenchymaltransitioninrenalcellcarcinoma
AT kondratyukrb markersofepithelialmesenchymaltransitioninrenalcellcarcinoma
AT gulkovyk markersofepithelialmesenchymaltransitioninrenalcellcarcinoma
AT chystiakovrs markersofepithelialmesenchymaltransitioninrenalcellcarcinoma
first_indexed 2023-10-18T21:33:11Z
last_indexed 2023-10-18T21:33:11Z
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