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Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo
Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injecti...
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Series: | Experimental Oncology |
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| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/145329 |
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irk-123456789-1453292019-01-21T01:24:08Z Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo Gevorkyan, L. Gambashidze, K. Short communications Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks. Treatment efficacy was evaluated by tumor growth inhibition. Results: In experimental animals treated with HTD, significant tumor growth inhibition has been registered: 73% at day 45th compared to the control group (p < 0.001). Conclusion: Treatment with HTD demonstrated high anticancer efficacy in vivo. Key Words: carcinogenesis, pH, hydroxyethylthiamine diphosphate, lipoic acid amide. 2014 Article Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145329 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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Short communications Short communications |
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Short communications Short communications Gevorkyan, L. Gambashidze, K. Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo Experimental Oncology |
| description |
Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks. Treatment efficacy was evaluated by tumor growth inhibition. Results: In experimental animals treated with HTD, significant tumor growth inhibition has been registered: 73% at day 45th compared to the control group (p < 0.001). Conclusion: Treatment with HTD demonstrated high anticancer efficacy in vivo. Key Words: carcinogenesis, pH, hydroxyethylthiamine diphosphate, lipoic acid amide. |
| format |
Article |
| author |
Gevorkyan, L. Gambashidze, K. |
| author_facet |
Gevorkyan, L. Gambashidze, K. |
| author_sort |
Gevorkyan, L. |
| title |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_short |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_full |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_fullStr |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_full_unstemmed |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_sort |
anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2014 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145329 |
| citation_txt |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
AT gevorkyanl anticancerefficacyofhydroxyethylthiaminediphosphateinvivo AT gambashidzek anticancerefficacyofhydroxyethylthiaminediphosphateinvivo |
| first_indexed |
2023-05-20T17:21:50Z |
| last_indexed |
2023-05-20T17:21:50Z |
| _version_ |
1796153126919602176 |