In search of molecular approaches to improving cancer therapy efficacy
The study of genome rearrangement sites using full genome sequences is an important approach to revealing the nature of cancer and finding effective ways for cancer treatment. The progress in DNA sequencing could make the procedure of whole genome reading close to routine procedure of lower cost. T...
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| Видавець: | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| Дата: | 2014 |
| Автори: | , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145331 |
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| Цитувати: | In search of molecular approaches to improving cancer therapy efficacy / E. Cherepenko, G. Telegeev // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 52-55. — Бібліогр.: 28 назв. — англ. |
Репозиторії
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irk-123456789-1453312019-01-21T01:24:05Z In search of molecular approaches to improving cancer therapy efficacy Cherepenko, E. Telegeev, G. Point of view The study of genome rearrangement sites using full genome sequences is an important approach to revealing the nature of cancer and finding effective ways for cancer treatment. The progress in DNA sequencing could make the procedure of whole genome reading close to routine procedure of lower cost. The personal analysis of rearranged ends (PARE) method used for rearrangement study is reviewed. PARE allows identifying of individual cancer biomarkers making personal medicine possible. Also, the progress in “liquid biopsy” technology based on detection of circulating tumor cells in the patient’s blood is shortly summarized. Another important approach is the discovered phenomenon of synthetic lethality causing cancer cell death due to appropriate combination of mutations in different genes or inhibitors of their protein products. Studies of genome rearrangements and synthetic lethality are considered promising for the development of effective cancer treatment approaches. Key Words: PARE, circulating tumor DNA, circulating tumor cells, liquid biopsy, synthetic lethality, cancer cell. 2014 Article In search of molecular approaches to improving cancer therapy efficacy / E. Cherepenko, G. Telegeev // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 52-55. — Бібліогр.: 28 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145331 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
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DSpace DC |
| language |
English |
| topic |
Point of view Point of view |
| spellingShingle |
Point of view Point of view Cherepenko, E. Telegeev, G. In search of molecular approaches to improving cancer therapy efficacy Experimental Oncology |
| description |
The study of genome rearrangement sites using full genome sequences is an important approach to revealing the nature of cancer and finding effective ways for cancer treatment. The progress in DNA sequencing could make the procedure of whole genome reading close to routine procedure of lower cost. The personal analysis of rearranged ends (PARE) method used for rearrangement study is reviewed. PARE allows identifying of individual cancer biomarkers making personal medicine possible. Also, the progress in “liquid biopsy” technology based on detection of circulating tumor cells in the patient’s blood is shortly summarized. Another important approach is the discovered phenomenon of synthetic lethality causing cancer cell death due to appropriate combination of mutations in different genes or inhibitors of their protein products. Studies of genome rearrangements and synthetic lethality are considered promising for the development of effective cancer treatment approaches. Key Words: PARE, circulating tumor DNA, circulating tumor cells, liquid biopsy, synthetic lethality, cancer cell. |
| format |
Article |
| author |
Cherepenko, E. Telegeev, G. |
| author_facet |
Cherepenko, E. Telegeev, G. |
| author_sort |
Cherepenko, E. |
| title |
In search of molecular approaches to improving cancer therapy efficacy |
| title_short |
In search of molecular approaches to improving cancer therapy efficacy |
| title_full |
In search of molecular approaches to improving cancer therapy efficacy |
| title_fullStr |
In search of molecular approaches to improving cancer therapy efficacy |
| title_full_unstemmed |
In search of molecular approaches to improving cancer therapy efficacy |
| title_sort |
in search of molecular approaches to improving cancer therapy efficacy |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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2014 |
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Point of view |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145331 |
| citation_txt |
In search of molecular approaches to improving cancer therapy efficacy / E. Cherepenko, G. Telegeev // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 52-55. — Бібліогр.: 28 назв. — англ. |
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Experimental Oncology |
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2023-05-20T17:21:50Z |
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