Anticancer substances of mushroom origin
The present status of investigations about the anticancer activity which is inherent to medicinal mushrooms, as well as their biomedical potential and future prospects are discussed. Mushroom products and extracts possess promising immunomodulating and anticancer effects, so the main biologically ac...
Збережено в:
| Дата: | 2014 |
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| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145333 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Anticancer substances of mushroom origin / T.S. Ivanova, T.A. Krupodorova, V.Y. Barshteyn, A.B. Artamonova, V.A. Shlyakhovenko // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 58-66. — Бібліогр.: 70 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-1453332019-01-21T01:23:38Z Anticancer substances of mushroom origin Ivanova, T.S. Krupodorova, T.A. Barshteyn, V.Y. Artamonova, A.B. Shlyakhovenko, V.A. Reviews The present status of investigations about the anticancer activity which is inherent to medicinal mushrooms, as well as their biomedical potential and future prospects are discussed. Mushroom products and extracts possess promising immunomodulating and anticancer effects, so the main biologically active substances of mushrooms responsible for immunomodulation and direct cytotoxicity toward cancer cell lines (including rarely mentioned groups of anticancer mushroom proteins), and the mechanisms of their antitumor action were analyzed. The existing to date clinical trials of mushroom substances are mentioned. Mushroom anticancer extracts, obtained by the different solvents, are outlined. Modern approaches of cancer treatment with implication of mushroom products, including DNA vaccinotherapy with mushroom immunomodulatory adjuvants, creation of prodrugs with mushroom lectins that can recognize glycoconjugates on the cancer cell surface, development of nanovectors etc. are discussed. The future prospects of mushroom anticancer substances application, including chemical modification of polysaccharides and terpenoids, gene engineering of proteins, and implementation of vaccines are reviewed. Key Words: mushrooms, anticancer substances, extracts, vaccinotherapy. 2014 Article Anticancer substances of mushroom origin / T.S. Ivanova, T.A. Krupodorova, V.Y. Barshteyn, A.B. Artamonova, V.A. Shlyakhovenko // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 58-66. — Бібліогр.: 70 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145333 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Ivanova, T.S. Krupodorova, T.A. Barshteyn, V.Y. Artamonova, A.B. Shlyakhovenko, V.A. Anticancer substances of mushroom origin Experimental Oncology |
| description |
The present status of investigations about the anticancer activity which is inherent to medicinal mushrooms, as well as their biomedical potential and future prospects are discussed. Mushroom products and extracts possess promising immunomodulating and anticancer effects, so the main biologically active substances of mushrooms responsible for immunomodulation and direct cytotoxicity toward cancer cell lines (including rarely mentioned groups of anticancer mushroom proteins), and the mechanisms of their antitumor action were analyzed. The existing to date clinical trials of mushroom substances are mentioned. Mushroom anticancer extracts, obtained by the different solvents, are outlined. Modern approaches of cancer treatment with implication of mushroom products, including DNA vaccinotherapy with mushroom immunomodulatory adjuvants, creation of prodrugs with mushroom lectins that can recognize glycoconjugates on the cancer cell surface, development of nanovectors etc. are discussed. The future prospects of mushroom anticancer substances application, including chemical modification of polysaccharides and terpenoids, gene engineering of proteins, and implementation of vaccines are reviewed. Key Words: mushrooms, anticancer substances, extracts, vaccinotherapy. |
| format |
Article |
| author |
Ivanova, T.S. Krupodorova, T.A. Barshteyn, V.Y. Artamonova, A.B. Shlyakhovenko, V.A. |
| author_facet |
Ivanova, T.S. Krupodorova, T.A. Barshteyn, V.Y. Artamonova, A.B. Shlyakhovenko, V.A. |
| author_sort |
Ivanova, T.S. |
| title |
Anticancer substances of mushroom origin |
| title_short |
Anticancer substances of mushroom origin |
| title_full |
Anticancer substances of mushroom origin |
| title_fullStr |
Anticancer substances of mushroom origin |
| title_full_unstemmed |
Anticancer substances of mushroom origin |
| title_sort |
anticancer substances of mushroom origin |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2014 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145333 |
| citation_txt |
Anticancer substances of mushroom origin / T.S. Ivanova, T.A. Krupodorova, V.Y. Barshteyn, A.B. Artamonova, V.A. Shlyakhovenko // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 58-66. — Бібліогр.: 70 назв. — англ. |
| series |
Experimental Oncology |
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AT ivanovats anticancersubstancesofmushroomorigin AT krupodorovata anticancersubstancesofmushroomorigin AT barshteynvy anticancersubstancesofmushroomorigin AT artamonovaab anticancersubstancesofmushroomorigin AT shlyakhovenkova anticancersubstancesofmushroomorigin |
| first_indexed |
2023-05-20T17:21:52Z |
| last_indexed |
2023-05-20T17:21:52Z |
| _version_ |
1796153127344275456 |