Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer

Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer

Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod...

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Дата:2014
Автори: Kiselev, V.I., Drukh, V.M., Muyzhnek, E.L., Kuznetsov, I.N., Pchelintseva, O.I., Paltsev, M.A.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/145337
Теги: Додати тег
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1453372019-01-21T01:24:04Z Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer Kiselev, V.I. Drukh, V.M. Muyzhnek, E.L. Kuznetsov, I.N. Pchelintseva, O.I. Paltsev, M.A. Original contributions Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% — treated versus control), dividing the tumor volumes from treatment groups with the control groups. Results: Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37th day of observation post inoculation. The highest antitumor activity was achieved on the 39th day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction. Key Words: 3,3´-diindolylmethane, bioavailability, anticancer activity, xenograft model, LNCaP cell line, preclinical studies. 2014 Article Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145337 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Kiselev, V.I.
Drukh, V.M.
Muyzhnek, E.L.
Kuznetsov, I.N.
Pchelintseva, O.I.
Paltsev, M.A.
Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
Experimental Oncology
description Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% — treated versus control), dividing the tumor volumes from treatment groups with the control groups. Results: Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37th day of observation post inoculation. The highest antitumor activity was achieved on the 39th day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction. Key Words: 3,3´-diindolylmethane, bioavailability, anticancer activity, xenograft model, LNCaP cell line, preclinical studies.
format Article
author Kiselev, V.I.
Drukh, V.M.
Muyzhnek, E.L.
Kuznetsov, I.N.
Pchelintseva, O.I.
Paltsev, M.A.
author_facet Kiselev, V.I.
Drukh, V.M.
Muyzhnek, E.L.
Kuznetsov, I.N.
Pchelintseva, O.I.
Paltsev, M.A.
author_sort Kiselev, V.I.
title Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_short Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_full Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_fullStr Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_full_unstemmed Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_sort preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2014
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145337
citation_txt Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ.
series Experimental Oncology
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first_indexed 2023-05-20T17:21:53Z
last_indexed 2023-05-20T17:21:53Z
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