Characterization of breast cancer DNA content profiles as a prognostic tool
Worldwide, breast cancer in women remains to be the most common malignancy that in a considerable proportion shows the resistance to genotoxic treatments and poor outcome. Chromosomal instability manifested as aneuploidy represents an integral characteristics of the malignant genotype not only beca...
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| Дата: | 2014 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145371 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Characterization of breast cancer DNA content profiles as a prognostic tool / B.I. Gerashchenko, A. Huna, J. Erenpreisa // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 219-225. — Бібліогр.: 74 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-1453712019-01-22T01:23:44Z Characterization of breast cancer DNA content profiles as a prognostic tool Gerashchenko, B.I. Huna, A. Erenpreisa, J. Reviews Worldwide, breast cancer in women remains to be the most common malignancy that in a considerable proportion shows the resistance to genotoxic treatments and poor outcome. Chromosomal instability manifested as aneuploidy represents an integral characteristics of the malignant genotype not only because of the selection of mutated aneuploid sub-clones that stipulate the tumor progression, but also because of the reversible endopolyploidy of tumor cells that serves for the endless maintenance of therapy-resistant tumor stem cells. Therefore, cytometric determination of DNA content in tissue samples for detecting malignancy, monitoring responses to therapy, and prognosing disease outcome needs to be revived. Both flow and image cytometry are most frequently used for generation of DNA content profiles (histograms), interpretation of which, however, may have some caveats. This review presents the major characterization criteria and analysis tools for breast cancer DNA histograms. Key Words: breast cancer, aneuploidy, DNA content analysis, DNA histogram, flow cytometry, image cytometry. 2014 Article Characterization of breast cancer DNA content profiles as a prognostic tool / B.I. Gerashchenko, A. Huna, J. Erenpreisa // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 219-225. — Бібліогр.: 74 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145371 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Gerashchenko, B.I. Huna, A. Erenpreisa, J. Characterization of breast cancer DNA content profiles as a prognostic tool Experimental Oncology |
| description |
Worldwide, breast cancer in women remains to be the most common malignancy that in a considerable proportion shows the resistance to genotoxic treatments and poor outcome. Chromosomal instability manifested as aneuploidy represents an integral characteristics of the malignant genotype not only because of the selection of mutated aneuploid sub-clones that stipulate the tumor progression, but also because of the reversible endopolyploidy of tumor cells that serves for the endless maintenance of therapy-resistant tumor stem cells. Therefore, cytometric determination of DNA content in tissue samples for detecting malignancy, monitoring responses to therapy, and prognosing disease outcome needs to be revived. Both flow and image cytometry are most frequently used for generation of DNA content profiles (histograms), interpretation of which, however, may have some caveats. This review presents the major characterization criteria and analysis tools for breast cancer DNA histograms. Key Words: breast cancer, aneuploidy, DNA content analysis, DNA histogram, flow cytometry, image cytometry. |
| format |
Article |
| author |
Gerashchenko, B.I. Huna, A. Erenpreisa, J. |
| author_facet |
Gerashchenko, B.I. Huna, A. Erenpreisa, J. |
| author_sort |
Gerashchenko, B.I. |
| title |
Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_short |
Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_full |
Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_fullStr |
Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_full_unstemmed |
Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_sort |
characterization of breast cancer dna content profiles as a prognostic tool |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2014 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145371 |
| citation_txt |
Characterization of breast cancer DNA content profiles as a prognostic tool / B.I. Gerashchenko, A. Huna, J. Erenpreisa // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 219-225. — Бібліогр.: 74 назв. — англ. |
| series |
Experimental Oncology |
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2023-05-20T17:21:58Z |
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2023-05-20T17:21:58Z |
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