Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats

• Дата: 2015
• Автори: Herrera-Covarrubias, D., Coria-Avila, G.A., Chavarra, X.P., Fernndez-Pomares, C., Manzo, J., Aranda-Abreu, G.E., Hernndez, M.E.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
• Назва видання: Experimental Oncology
• Теми: Original contributions
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/145448
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats / D. Herrera-Covarrubias, G.A. Coria-Avila, X.P. Chavarra, C. Fernndez-Pomares, J. Manzo, G.E. Aranda-Abreu, M.E. Hernndez // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 13-18. — Бібліогр.: 47 назв. — англ.

Evidence indicates that prolactin plays a crucial role in the normal function and development of the prostate, but abnormal high levels of the hormone are associated with hyperplasia and cancer of the gland. Aims: The present study was designed to describe the progressive specific histological abnormalities in the prostate of rats with chronic hyperprolactinemia. Material and Methods: Prolactin was administered during 4; 12 or 24 weeks, and the resulting prostatic alterations were compared with control rats, and also with those treated with testosterone, or the combination of prolactin + testosterone. Results: Rats treated with prolactin, testosterone or prolactin + testosterone expressed precancerous histological abnormalities in the dorsolateral and ventral portions of the prostate as early as in 4 weeks of treatment, but in all cases the malignancy increased after 12 or 24 weeks of treatment. Conclusion: Our study confirms that chronic hyperprolactinemia is a cause of prostate precancerous pathologies. Key Words: prolactin, prostate, cancer, dysplasia, testosterone.