Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats
Evidence indicates that prolactin plays a crucial role in the normal function and development of the prostate, but abnormal high levels of the hormone are associated with hyperplasia and cancer of the gland. Aims: The present study was designed to describe the progressive specific histological abnor...
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| Видавець: | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| Дата: | 2015 |
| Автори: | , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145448 |
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| Цитувати: | Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats / D. Herrera-Covarrubias, G.A. Coria-Avila, X.P. Chavarra, C. Fernndez-Pomares, J. Manzo, G.E. Aranda-Abreu, M.E. Hernndez // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 13-18. — Бібліогр.: 47 назв. — англ. |
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irk-123456789-1454482019-01-22T01:23:43Z Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats Herrera-Covarrubias, D. Coria-Avila, G.A. Chavarra, X.P. Fernndez-Pomares, C. Manzo, J. Aranda-Abreu, G.E. Hernndez, M.E. Original contributions Evidence indicates that prolactin plays a crucial role in the normal function and development of the prostate, but abnormal high levels of the hormone are associated with hyperplasia and cancer of the gland. Aims: The present study was designed to describe the progressive specific histological abnormalities in the prostate of rats with chronic hyperprolactinemia. Material and Methods: Prolactin was administered during 4; 12 or 24 weeks, and the resulting prostatic alterations were compared with control rats, and also with those treated with testosterone, or the combination of prolactin + testosterone. Results: Rats treated with prolactin, testosterone or prolactin + testosterone expressed precancerous histological abnormalities in the dorsolateral and ventral portions of the prostate as early as in 4 weeks of treatment, but in all cases the malignancy increased after 12 or 24 weeks of treatment. Conclusion: Our study confirms that chronic hyperprolactinemia is a cause of prostate precancerous pathologies. Key Words: prolactin, prostate, cancer, dysplasia, testosterone. 2015 Article Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats / D. Herrera-Covarrubias, G.A. Coria-Avila, X.P. Chavarra, C. Fernndez-Pomares, J. Manzo, G.E. Aranda-Abreu, M.E. Hernndez // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 13-18. — Бібліогр.: 47 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145448 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Herrera-Covarrubias, D. Coria-Avila, G.A. Chavarra, X.P. Fernndez-Pomares, C. Manzo, J. Aranda-Abreu, G.E. Hernndez, M.E. Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats Experimental Oncology |
| description |
Evidence indicates that prolactin plays a crucial role in the normal function and development of the prostate, but abnormal high levels of the hormone are associated with hyperplasia and cancer of the gland. Aims: The present study was designed to describe the progressive specific histological abnormalities in the prostate of rats with chronic hyperprolactinemia. Material and Methods: Prolactin was administered during 4; 12 or 24 weeks, and the resulting prostatic alterations were compared with control rats, and also with those treated with testosterone, or the combination of prolactin + testosterone. Results: Rats treated with prolactin, testosterone or prolactin + testosterone expressed precancerous histological abnormalities in the dorsolateral and ventral portions of the prostate as early as in 4 weeks of treatment, but in all cases the malignancy increased after 12 or 24 weeks of treatment. Conclusion: Our study confirms that chronic hyperprolactinemia is a cause of prostate precancerous pathologies. Key Words: prolactin, prostate, cancer, dysplasia, testosterone. |
| format |
Article |
| author |
Herrera-Covarrubias, D. Coria-Avila, G.A. Chavarra, X.P. Fernndez-Pomares, C. Manzo, J. Aranda-Abreu, G.E. Hernndez, M.E. |
| author_facet |
Herrera-Covarrubias, D. Coria-Avila, G.A. Chavarra, X.P. Fernndez-Pomares, C. Manzo, J. Aranda-Abreu, G.E. Hernndez, M.E. |
| author_sort |
Herrera-Covarrubias, D. |
| title |
Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats |
| title_short |
Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats |
| title_full |
Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats |
| title_fullStr |
Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats |
| title_full_unstemmed |
Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats |
| title_sort |
long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2015 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145448 |
| citation_txt |
Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats / D. Herrera-Covarrubias, G.A. Coria-Avila, X.P. Chavarra, C. Fernndez-Pomares, J. Manzo, G.E. Aranda-Abreu, M.E. Hernndez // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 13-18. — Бібліогр.: 47 назв. — англ. |
| series |
Experimental Oncology |
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