Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor

Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor

Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colony-stimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that enterosorption causes prominent myeloprotective activity also. St...

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Дата:2015
Автори: Shevchuk, O.O., Posokhova, K.A., Todor, I.N., Lukianova, N.Yu., Nikolaev, V.G., Chekhun, V.F.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/145469
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor / O.O. Shevchuk, K.A. Posokhova, I.N. Todor, N.Yu. Lukianova, V.G. Nikolaev, V.F. Chekhun // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 135-138. — Бібліогр.: 26 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1454692019-01-23T01:23:07Z Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor Shevchuk, O.O. Posokhova, K.A. Todor, I.N. Lukianova, N.Yu. Nikolaev, V.G. Chekhun, V.F. Original contributions Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colony-stimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that enterosorption causes prominent myeloprotective activity also. Still, no trial was performed to combine both of them. Aim: To study the influence of combination of enterosorption and pharmaceutical analogue of naturally occurring G-CSF (filgrastim) on bone marrow protection and the growth of grafted tumor in a case of injection of melphalan (Mel). Materials and Methods: Mel injections were used for promotion of bone marrow suppression in rats. Carbon granulated enterosorbent C2 (IEPOR) was used for providing of enteral sorption detoxifying therapy. Filgrastim was used to increase white blood cells (WBC) count. Results: The simultaneous usage of enterosorption and filgrastim had maximum effectiveness for restoring of all types of blood cells. WBC count was higher by 138.3% compared with the Mel group. The increase of platelets count by 98.5% was also observed. In the group (Mel + C2 + filgrastim) the absolute neutrophils count was twofold higher, in comparison with rats of Mel group. Conclusion: Simultaneous admi­nistration of G-CSF-analogue and carbonic enterosorbent C2 is a perspective approach for bone marrow protection, when the cytostatic drug melphalan is used. Such combination demonstrates prominent positive impact on restoring of all types of blood cells and had no influence on the antitumor efficacy. Key Words: myelotoxicity, melphalan, enterosorption, granulocyte colony-stimulating factor. 2015 Article Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor / O.O. Shevchuk, K.A. Posokhova, I.N. Todor, N.Yu. Lukianova, V.G. Nikolaev, V.F. Chekhun // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 135-138. — Бібліогр.: 26 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145469 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Shevchuk, O.O.
Posokhova, K.A.
Todor, I.N.
Lukianova, N.Yu.
Nikolaev, V.G.
Chekhun, V.F.
Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor
Experimental Oncology
description Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colony-stimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that enterosorption causes prominent myeloprotective activity also. Still, no trial was performed to combine both of them. Aim: To study the influence of combination of enterosorption and pharmaceutical analogue of naturally occurring G-CSF (filgrastim) on bone marrow protection and the growth of grafted tumor in a case of injection of melphalan (Mel). Materials and Methods: Mel injections were used for promotion of bone marrow suppression in rats. Carbon granulated enterosorbent C2 (IEPOR) was used for providing of enteral sorption detoxifying therapy. Filgrastim was used to increase white blood cells (WBC) count. Results: The simultaneous usage of enterosorption and filgrastim had maximum effectiveness for restoring of all types of blood cells. WBC count was higher by 138.3% compared with the Mel group. The increase of platelets count by 98.5% was also observed. In the group (Mel + C2 + filgrastim) the absolute neutrophils count was twofold higher, in comparison with rats of Mel group. Conclusion: Simultaneous admi­nistration of G-CSF-analogue and carbonic enterosorbent C2 is a perspective approach for bone marrow protection, when the cytostatic drug melphalan is used. Such combination demonstrates prominent positive impact on restoring of all types of blood cells and had no influence on the antitumor efficacy. Key Words: myelotoxicity, melphalan, enterosorption, granulocyte colony-stimulating factor.
format Article
author Shevchuk, O.O.
Posokhova, K.A.
Todor, I.N.
Lukianova, N.Yu.
Nikolaev, V.G.
Chekhun, V.F.
author_facet Shevchuk, O.O.
Posokhova, K.A.
Todor, I.N.
Lukianova, N.Yu.
Nikolaev, V.G.
Chekhun, V.F.
author_sort Shevchuk, O.O.
title Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor
title_short Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor
title_full Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor
title_fullStr Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor
title_full_unstemmed Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor
title_sort prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2015
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145469
citation_txt Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor / O.O. Shevchuk, K.A. Posokhova, I.N. Todor, N.Yu. Lukianova, V.G. Nikolaev, V.F. Chekhun // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 135-138. — Бібліогр.: 26 назв. — англ.
series Experimental Oncology
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first_indexed 2023-05-20T17:22:14Z
last_indexed 2023-05-20T17:22:14Z
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