Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer
Background: Lapatinib alone or in combination with other agents, mostly capecitabine is used for patients with advanced/metastatic HER2 positive breast cancer (HER2+BC) after progression on trastuzumab based therapy. Here we report our experience with lapatinib based therapy in this setting. Materia...
Збережено в:
| Дата: | 2015 |
|---|---|
| Автори: | , , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
|
| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145471 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer / J. Zekri, M. Mokhtar, S.M. Karim, T. Darwish, M. Al-Foheidi, A. Rizvi, S. Al-Rehaily, M. Mahrous, M. Mansour // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 146-150. — Бібліогр.: 24 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
irk-123456789-145471 |
|---|---|
| record_format |
dspace |
| spelling |
irk-123456789-1454712019-01-23T01:23:24Z Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer Zekri, J. Mokhtar, M. Karim, S.M. Darwish, T. Al-Foheidi, M. Rizvi, A. Al-Rehaily, S. Mahrous, M. Mansour, M. Original contributions Background: Lapatinib alone or in combination with other agents, mostly capecitabine is used for patients with advanced/metastatic HER2 positive breast cancer (HER2+BC) after progression on trastuzumab based therapy. Here we report our experience with lapatinib based therapy in this setting. Material and Methods: 67 consecutive patients received lapatinib based therapy. 58 (86.6%) received lapatinib + capecitabine (LC), 7 (10.4%) with other agents and 2 (3.0%) as single agent lapatinib. Data was collected from patients’ records retrospectively. Results: Objective response to lapatinib based therapy in 64 evaluable patients was 64.0% in all patients and 64.0% in patients who received LC. Median progression free survival and overall survival were 10 and 27 months in all patients and 10 and 17 months in patients who received LC, respectively. 16 (24.0%) patients had dose delay > 1 week and/or dose reduction. Conclusion: Lapatinib based therapy is an effective treatment for women with advanced/metastatic HER2+BC after prior exposure to trastuzumab. It yields meaningful response rates, progression free and overall survival. Some patients require dose adjustments. Key Words: lapatinib-based therapy, metastatic breast cancer, HER2 positive breast cancer, trastuzumab. 2015 Article Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer / J. Zekri, M. Mokhtar, S.M. Karim, T. Darwish, M. Al-Foheidi, A. Rizvi, S. Al-Rehaily, M. Mahrous, M. Mansour // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 146-150. — Бібліогр.: 24 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145471 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Zekri, J. Mokhtar, M. Karim, S.M. Darwish, T. Al-Foheidi, M. Rizvi, A. Al-Rehaily, S. Mahrous, M. Mansour, M. Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer Experimental Oncology |
| description |
Background: Lapatinib alone or in combination with other agents, mostly capecitabine is used for patients with advanced/metastatic HER2 positive breast cancer (HER2+BC) after progression on trastuzumab based therapy. Here we report our experience with lapatinib based therapy in this setting. Material and Methods: 67 consecutive patients received lapatinib based therapy. 58 (86.6%) received lapatinib + capecitabine (LC), 7 (10.4%) with other agents and 2 (3.0%) as single agent lapatinib. Data was collected from patients’ records retrospectively. Results: Objective response to lapatinib based therapy in 64 evaluable patients was 64.0% in all patients and 64.0% in patients who received LC. Median progression free survival and overall survival were 10 and 27 months in all patients and 10 and 17 months in patients who received LC, respectively. 16 (24.0%) patients had dose delay > 1 week and/or dose reduction. Conclusion: Lapatinib based therapy is an effective treatment for women with advanced/metastatic HER2+BC after prior exposure to trastuzumab. It yields meaningful response rates, progression free and overall survival. Some patients require dose adjustments. Key Words: lapatinib-based therapy, metastatic breast cancer, HER2 positive breast cancer, trastuzumab. |
| format |
Article |
| author |
Zekri, J. Mokhtar, M. Karim, S.M. Darwish, T. Al-Foheidi, M. Rizvi, A. Al-Rehaily, S. Mahrous, M. Mansour, M. |
| author_facet |
Zekri, J. Mokhtar, M. Karim, S.M. Darwish, T. Al-Foheidi, M. Rizvi, A. Al-Rehaily, S. Mahrous, M. Mansour, M. |
| author_sort |
Zekri, J. |
| title |
Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer |
| title_short |
Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer |
| title_full |
Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer |
| title_fullStr |
Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer |
| title_full_unstemmed |
Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer |
| title_sort |
lapatinib-based therapy for women with advanced/metastatic her2 positive breast cancer |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2015 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145471 |
| citation_txt |
Lapatinib-based therapy for women with advanced/metastatic HER2 positive breast cancer / J. Zekri, M. Mokhtar, S.M. Karim, T. Darwish, M. Al-Foheidi, A. Rizvi, S. Al-Rehaily, M. Mahrous, M. Mansour // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 146-150. — Бібліогр.: 24 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
AT zekrij lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer AT mokhtarm lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer AT karimsm lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer AT darwisht lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer AT alfoheidim lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer AT rizvia lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer AT alrehailys lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer AT mahrousm lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer AT mansourm lapatinibbasedtherapyforwomenwithadvancedmetastaticher2positivebreastcancer |
| first_indexed |
2023-05-20T17:22:14Z |
| last_indexed |
2023-05-20T17:22:14Z |
| _version_ |
1796153141405679616 |