Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma

Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma

Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted...

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Дата:2015
Автори: Sarnatskaya, V.V., Nikolaev, V.G., Yushko, L.A., Paziuk, L.M., Karaman, O.M., Fedosova, N.I., Kolesnik, D.L., Dasyukevich, O.I., Gorbik, G.V., Maslenny, V.N., Solyanik, G.I.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/145543
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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spelling irk-123456789-1455432019-01-23T01:23:17Z Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma Sarnatskaya, V.V. Nikolaev, V.G. Yushko, L.A. Paziuk, L.M. Karaman, O.M. Fedosova, N.I. Kolesnik, D.L. Dasyukevich, O.I. Gorbik, G.V. Maslenny, V.N. Solyanik, G.I. Original contributions Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted LLC/R9. Enterosorbent HSGD was administered daily at a dose of 0.625 g/kg for 2 weeks starting from 7th day after tumor cell transplantation. When enterosorption was completed, an analysis of peripheral blood, biochemical indices and morphological structure of tumor, lung, liver, spleen and thymus was carried out by standard methods. Results: It has been shown that administration of enterosorbent did not affect LLC/R9 growth but resulted in nearly two fold decrease of the volume of lung metastases (p < 0.05). Erythrocyte number and hemoglobin level were higher by 30.0% (p < 0.05) and 23.3% (p < 0.05), respectively, in mice treated with enterosorbents as compared to untreated animals. In addition sorbent treatment completely normalized the thrombocyte index resulting in elevation of platelet number by 54.5% (p < 0.01) up to their level in intact mice. The morphological examination of liver and biochemical analysis of peripheral blood evidenced on significant positive correcting effect of enterosorption on histological structure of this organ and its functional acti­vity. Normalization of total proteins and serum albumin level as well as significant decrease of total lipid concentration by 29% (p < 0.01) in blood of treated mice were observed. Conclusion: Positive influence of microgranulated carbon sorbent on some hematological, morphological and biochemical indices of tumor associated symptoms in LLC/R9-bearing mice denotes that enterosorption-based therapy can be considered as a prospective treatment for correction of some paraneoplastic syndrome signs in cancer patients. Key Words: paraneoplastic syndrome, Lewis lung carcinoma LLC/R9, enterosorption. 2015 Article Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145543 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Sarnatskaya, V.V.
Nikolaev, V.G.
Yushko, L.A.
Paziuk, L.M.
Karaman, O.M.
Fedosova, N.I.
Kolesnik, D.L.
Dasyukevich, O.I.
Gorbik, G.V.
Maslenny, V.N.
Solyanik, G.I.
Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
Experimental Oncology
description Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted LLC/R9. Enterosorbent HSGD was administered daily at a dose of 0.625 g/kg for 2 weeks starting from 7th day after tumor cell transplantation. When enterosorption was completed, an analysis of peripheral blood, biochemical indices and morphological structure of tumor, lung, liver, spleen and thymus was carried out by standard methods. Results: It has been shown that administration of enterosorbent did not affect LLC/R9 growth but resulted in nearly two fold decrease of the volume of lung metastases (p < 0.05). Erythrocyte number and hemoglobin level were higher by 30.0% (p < 0.05) and 23.3% (p < 0.05), respectively, in mice treated with enterosorbents as compared to untreated animals. In addition sorbent treatment completely normalized the thrombocyte index resulting in elevation of platelet number by 54.5% (p < 0.01) up to their level in intact mice. The morphological examination of liver and biochemical analysis of peripheral blood evidenced on significant positive correcting effect of enterosorption on histological structure of this organ and its functional acti­vity. Normalization of total proteins and serum albumin level as well as significant decrease of total lipid concentration by 29% (p < 0.01) in blood of treated mice were observed. Conclusion: Positive influence of microgranulated carbon sorbent on some hematological, morphological and biochemical indices of tumor associated symptoms in LLC/R9-bearing mice denotes that enterosorption-based therapy can be considered as a prospective treatment for correction of some paraneoplastic syndrome signs in cancer patients. Key Words: paraneoplastic syndrome, Lewis lung carcinoma LLC/R9, enterosorption.
format Article
author Sarnatskaya, V.V.
Nikolaev, V.G.
Yushko, L.A.
Paziuk, L.M.
Karaman, O.M.
Fedosova, N.I.
Kolesnik, D.L.
Dasyukevich, O.I.
Gorbik, G.V.
Maslenny, V.N.
Solyanik, G.I.
author_facet Sarnatskaya, V.V.
Nikolaev, V.G.
Yushko, L.A.
Paziuk, L.M.
Karaman, O.M.
Fedosova, N.I.
Kolesnik, D.L.
Dasyukevich, O.I.
Gorbik, G.V.
Maslenny, V.N.
Solyanik, G.I.
author_sort Sarnatskaya, V.V.
title Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_short Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_full Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_fullStr Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_full_unstemmed Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_sort effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2015
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145543
citation_txt Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ.
series Experimental Oncology
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first_indexed 2023-05-20T17:22:28Z
last_indexed 2023-05-20T17:22:28Z
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