Increased homocysteine plasma levels in breast cancer patients of a Mexican population

Increased homocysteine plasma levels in breast cancer patients of a Mexican population

Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Mate...

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Datum:2018
Hauptverfasser: Varela Almanza, K.M., Puebla-Pérez, A.M., Delgado-Saucedo, J.I., Rodríguez-Arévalo, F., Zúñiga-González, G.M., Figuera, L.E., Morán-Mendoza, A., Gallegos-Arreola, M.P.
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Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2018
Schriftenreihe:Experimental Oncology
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Original contributions
Online Zugang:http://dspace.nbuv.gov.ua/handle/123456789/145566
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ.

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spelling irk-123456789-1455662019-01-25T01:23:30Z Increased homocysteine plasma levels in breast cancer patients of a Mexican population Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. Original contributions Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population. 2018 Article Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145566 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Varela Almanza, K.M.
Puebla-Pérez, A.M.
Delgado-Saucedo, J.I.
Rodríguez-Arévalo, F.
Zúñiga-González, G.M.
Figuera, L.E.
Morán-Mendoza, A.
Gallegos-Arreola, M.P.
Increased homocysteine plasma levels in breast cancer patients of a Mexican population
Experimental Oncology
description Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population.
format Article
author Varela Almanza, K.M.
Puebla-Pérez, A.M.
Delgado-Saucedo, J.I.
Rodríguez-Arévalo, F.
Zúñiga-González, G.M.
Figuera, L.E.
Morán-Mendoza, A.
Gallegos-Arreola, M.P.
author_facet Varela Almanza, K.M.
Puebla-Pérez, A.M.
Delgado-Saucedo, J.I.
Rodríguez-Arévalo, F.
Zúñiga-González, G.M.
Figuera, L.E.
Morán-Mendoza, A.
Gallegos-Arreola, M.P.
author_sort Varela Almanza, K.M.
title Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_short Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_full Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_fullStr Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_full_unstemmed Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_sort increased homocysteine plasma levels in breast cancer patients of a mexican population
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2018
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145566
citation_txt Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ.
series Experimental Oncology
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first_indexed 2025-07-10T21:58:10Z
last_indexed 2025-07-10T21:58:10Z
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