Increased homocysteine plasma levels in breast cancer patients of a Mexican population
Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Mate...
Збережено в:
| Дата: | 2018 |
|---|---|
| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2018
|
| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145566 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
irk-123456789-145566 |
|---|---|
| record_format |
dspace |
| spelling |
irk-123456789-1455662019-01-25T01:23:30Z Increased homocysteine plasma levels in breast cancer patients of a Mexican population Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. Original contributions Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population. 2018 Article Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145566 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. Increased homocysteine plasma levels in breast cancer patients of a Mexican population Experimental Oncology |
| description |
Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population. |
| format |
Article |
| author |
Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. |
| author_facet |
Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. |
| author_sort |
Varela Almanza, K.M. |
| title |
Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_short |
Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_full |
Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_fullStr |
Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_full_unstemmed |
Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_sort |
increased homocysteine plasma levels in breast cancer patients of a mexican population |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2018 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145566 |
| citation_txt |
Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
AT varelaalmanzakm increasedhomocysteineplasmalevelsinbreastcancerpatientsofamexicanpopulation AT pueblaperezam increasedhomocysteineplasmalevelsinbreastcancerpatientsofamexicanpopulation AT delgadosaucedoji increasedhomocysteineplasmalevelsinbreastcancerpatientsofamexicanpopulation AT rodriguezarevalof increasedhomocysteineplasmalevelsinbreastcancerpatientsofamexicanpopulation AT zunigagonzalezgm increasedhomocysteineplasmalevelsinbreastcancerpatientsofamexicanpopulation AT figuerale increasedhomocysteineplasmalevelsinbreastcancerpatientsofamexicanpopulation AT moranmendozaa increasedhomocysteineplasmalevelsinbreastcancerpatientsofamexicanpopulation AT gallegosarreolamp increasedhomocysteineplasmalevelsinbreastcancerpatientsofamexicanpopulation |
| first_indexed |
2023-05-20T17:22:32Z |
| last_indexed |
2023-05-20T17:22:32Z |
| _version_ |
1796153152697794560 |