Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties

Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties

Aim: To determine biological and clinical features of papillary and follicular thyroid carcinomas associated or not associated with chronic thyroiditis. Materials and Methods: The study was conducted by retrospective analysis of medical histories of 2,459 patients with thyroid cancer. Tumor size, it...

Повний опис

Збережено в:
Бібліографічні деталі
Видавець:Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Дата:2018
Автори: Myshunina, T.M., Guda, B.D., Bolgov, M.Yu., Mikhailenko, N.I., Tronko, N.D.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2018
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/145571
Теги: Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
Цитувати:Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties / T.M. Myshunina, B.D. Guda, M.Yu. Bolgov, N.I. Mikhailenko, N.D. Tronko // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 128–131. — Бібліогр.: 29 назв. — англ.

Репозиторії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-145571
record_format dspace
spelling irk-123456789-1455712019-01-25T01:23:11Z Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties Myshunina, T.M. Guda, B.D. Bolgov, M.Yu. Mikhailenko, N.I. Tronko, N.D. Original contributions Aim: To determine biological and clinical features of papillary and follicular thyroid carcinomas associated or not associated with chronic thyroiditis. Materials and Methods: The study was conducted by retrospective analysis of medical histories of 2,459 patients with thyroid cancer. Tumor size, its category according to the TNM system, multi-focal properties of tumor growth, carcinoma invasiveness, as well as disease stage, rates of relapses and metastasis, and also cumulative survival rates were analyzed. Results: The tumor size in patients with papillary or follicular carcinoma associated with thyroiditis was smaller compared to the patients without thyroiditis. In the first case, the invasion frequency into extrathyroid structure and into the capsule was also lower. Multi-focal growth of both carcinoma types was registered more frequently in the presence of thyroiditis. The frequency of papillary carcinoma metastasis to lateral cervical lymph nodes was lower in the presence of thyroiditis, the frequency being equal for metastasis into lymph nodes of the VI lymph outflow zone in both groups of patients (with and without thyroiditis). In the presence of thyroiditis, the frequency of distant papillary carcinoma metastasis was decreased, no metastases were detected in patients with follicular carcinoma. In the group of patients with papillary carcinoma there was found no relation between the presence of thyroiditis and disease stage, relapse rates, and mortality levels; however, the risk of follicular carcinoma relapse was significantly lower in patients with thyroiditis. Conclusions: The presence of chronic thyroiditis in papillary carcinoma patients showed a certain positive impact on the course of the disease, in particular, primary tumor growth, invasion, and metastasis. Such effect is even more expressed in the patients with follicular thyroid carcinoma. Key Words: papillary and follicular thyroid carcinomas, autoimmune thyroiditis. 2018 Article Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties / T.M. Myshunina, B.D. Guda, M.Yu. Bolgov, N.I. Mikhailenko, N.D. Tronko // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 128–131. — Бібліогр.: 29 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145571 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Myshunina, T.M.
Guda, B.D.
Bolgov, M.Yu.
Mikhailenko, N.I.
Tronko, N.D.
Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties
Experimental Oncology
description Aim: To determine biological and clinical features of papillary and follicular thyroid carcinomas associated or not associated with chronic thyroiditis. Materials and Methods: The study was conducted by retrospective analysis of medical histories of 2,459 patients with thyroid cancer. Tumor size, its category according to the TNM system, multi-focal properties of tumor growth, carcinoma invasiveness, as well as disease stage, rates of relapses and metastasis, and also cumulative survival rates were analyzed. Results: The tumor size in patients with papillary or follicular carcinoma associated with thyroiditis was smaller compared to the patients without thyroiditis. In the first case, the invasion frequency into extrathyroid structure and into the capsule was also lower. Multi-focal growth of both carcinoma types was registered more frequently in the presence of thyroiditis. The frequency of papillary carcinoma metastasis to lateral cervical lymph nodes was lower in the presence of thyroiditis, the frequency being equal for metastasis into lymph nodes of the VI lymph outflow zone in both groups of patients (with and without thyroiditis). In the presence of thyroiditis, the frequency of distant papillary carcinoma metastasis was decreased, no metastases were detected in patients with follicular carcinoma. In the group of patients with papillary carcinoma there was found no relation between the presence of thyroiditis and disease stage, relapse rates, and mortality levels; however, the risk of follicular carcinoma relapse was significantly lower in patients with thyroiditis. Conclusions: The presence of chronic thyroiditis in papillary carcinoma patients showed a certain positive impact on the course of the disease, in particular, primary tumor growth, invasion, and metastasis. Such effect is even more expressed in the patients with follicular thyroid carcinoma. Key Words: papillary and follicular thyroid carcinomas, autoimmune thyroiditis.
format Article
author Myshunina, T.M.
Guda, B.D.
Bolgov, M.Yu.
Mikhailenko, N.I.
Tronko, N.D.
author_facet Myshunina, T.M.
Guda, B.D.
Bolgov, M.Yu.
Mikhailenko, N.I.
Tronko, N.D.
author_sort Myshunina, T.M.
title Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties
title_short Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties
title_full Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties
title_fullStr Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties
title_full_unstemmed Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties
title_sort differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2018
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145571
citation_txt Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties / T.M. Myshunina, B.D. Guda, M.Yu. Bolgov, N.I. Mikhailenko, N.D. Tronko // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 128–131. — Бібліогр.: 29 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT myshuninatm differentiatedthyroidcarcinomasassociatedwithchronicthyroiditisbiologicalandclinicalproperties
AT gudabd differentiatedthyroidcarcinomasassociatedwithchronicthyroiditisbiologicalandclinicalproperties
AT bolgovmyu differentiatedthyroidcarcinomasassociatedwithchronicthyroiditisbiologicalandclinicalproperties
AT mikhailenkoni differentiatedthyroidcarcinomasassociatedwithchronicthyroiditisbiologicalandclinicalproperties
AT tronkond differentiatedthyroidcarcinomasassociatedwithchronicthyroiditisbiologicalandclinicalproperties
first_indexed 2023-05-20T17:22:33Z
last_indexed 2023-05-20T17:22:33Z
_version_ 1796153153227325440

Схожі ресурси