The state of bone metabolism in lung cancer patients
In recent years, we have discussed the correlation of malignant tumor process with the development of osteoporosis, which can be exacerbated by ongoing chemotherapy and radiation therapy. The aim of the work was to assess the status of bone metabolism in 32 untreated patients with lung cancer withou...
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| Видавець: | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| Дата: | 2018 |
| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2018
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145588 |
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| Цитувати: | The state of bone metabolism in lung cancer patients / Y.V. Dumanskyy, O.V. Syniachenko, Ph.A. Stepko, G.S. Taktashov, O.Y. Chernyshova // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 136–139. — Бібліогр.: 19 назв. — англ. |
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irk-123456789-1455882019-01-25T01:23:13Z The state of bone metabolism in lung cancer patients Dumansky, Y.V. Syniachenko, O.V. Stepko, Ph.A. Taktashov, G.S. Chernyshova, O.Y. Original contributions In recent years, we have discussed the correlation of malignant tumor process with the development of osteoporosis, which can be exacerbated by ongoing chemotherapy and radiation therapy. The aim of the work was to assess the status of bone metabolism in 32 untreated patients with lung cancer without metastasis. Materials and Methods: Patients underwent dual-energy X-ray osteodensitometry of proximal part of femoral bone. Osteopontin (OP), osteocalcin (OC) and alkaline phosphatase (AP) parameters were studied in blood, as well as osteo-associated chemical elements. Results: Lung cancer proceeds with severe disorders of bone metabolism, which is accompanied by an increase in blood levels of OP, OС, AP, phosphorus, lithium, lead, strontium and cobalt against a decrease of calcium, magnesium and manganese, which were observed in 75; 78; 31; 100; 66; 47; 44; 3; 100; 100, and 6% of patients, respectively; such disorder was associated with a morphological variant of the tumor (cobalt) and stage of disease (calcium, magnesium, manganese, strontium), development of osteodeficit (OP, OC, AR, strontium, zinc). Osteodeficit in the form of osteopenia and osteoporosis is observed more common in women, in every second patient, and osteodensimetric T-score depends on the age of patients, directly correlates with the values of the OP and OC, and inversely — with a zincemia rate. Conclusions: The disorders of bone metabolism in patients with lung cancer indicate the need for the development of antiosteoporosis treatment for cancer patients. Key Words: lung cancer, bone metabolism. 2018 Article The state of bone metabolism in lung cancer patients / Y.V. Dumanskyy, O.V. Syniachenko, Ph.A. Stepko, G.S. Taktashov, O.Y. Chernyshova // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 136–139. — Бібліогр.: 19 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145588 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Dumansky, Y.V. Syniachenko, O.V. Stepko, Ph.A. Taktashov, G.S. Chernyshova, O.Y. The state of bone metabolism in lung cancer patients Experimental Oncology |
| description |
In recent years, we have discussed the correlation of malignant tumor process with the development of osteoporosis, which can be exacerbated by ongoing chemotherapy and radiation therapy. The aim of the work was to assess the status of bone metabolism in 32 untreated patients with lung cancer without metastasis. Materials and Methods: Patients underwent dual-energy X-ray osteodensitometry of proximal part of femoral bone. Osteopontin (OP), osteocalcin (OC) and alkaline phosphatase (AP) parameters were studied in blood, as well as osteo-associated chemical elements. Results: Lung cancer proceeds with severe disorders of bone metabolism, which is accompanied by an increase in blood levels of OP, OС, AP, phosphorus, lithium, lead, strontium and cobalt against a decrease of calcium, magnesium and manganese, which were observed in 75; 78; 31; 100; 66; 47; 44; 3; 100; 100, and 6% of patients, respectively; such disorder was associated with a morphological variant of the tumor (cobalt) and stage of disease (calcium, magnesium, manganese, strontium), development of osteodeficit (OP, OC, AR, strontium, zinc). Osteodeficit in the form of osteopenia and osteoporosis is observed more common in women, in every second patient, and osteodensimetric T-score depends on the age of patients, directly correlates with the values of the OP and OC, and inversely — with a zincemia rate. Conclusions: The disorders of bone metabolism in patients with lung cancer indicate the need for the development of antiosteoporosis treatment for cancer patients. Key Words: lung cancer, bone metabolism. |
| format |
Article |
| author |
Dumansky, Y.V. Syniachenko, O.V. Stepko, Ph.A. Taktashov, G.S. Chernyshova, O.Y. |
| author_facet |
Dumansky, Y.V. Syniachenko, O.V. Stepko, Ph.A. Taktashov, G.S. Chernyshova, O.Y. |
| author_sort |
Dumansky, Y.V. |
| title |
The state of bone metabolism in lung cancer patients |
| title_short |
The state of bone metabolism in lung cancer patients |
| title_full |
The state of bone metabolism in lung cancer patients |
| title_fullStr |
The state of bone metabolism in lung cancer patients |
| title_full_unstemmed |
The state of bone metabolism in lung cancer patients |
| title_sort |
state of bone metabolism in lung cancer patients |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2018 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145588 |
| citation_txt |
The state of bone metabolism in lung cancer patients / Y.V. Dumanskyy, O.V. Syniachenko, Ph.A. Stepko, G.S. Taktashov, O.Y. Chernyshova // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 136–139. — Бібліогр.: 19 назв. — англ. |
| series |
Experimental Oncology |
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