Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma
Aim: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistoch...
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| Дата: | 2018 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2018
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| Назва видання: | Experimental Oncology |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/145637 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I.P. Nesina, N.P. Iurchenko, L.G. Buchynska // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 218–222. — Бібліогр.: 33 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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irk-123456789-1456372019-01-26T01:23:19Z Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma Nesina, I.P. Iurchenko, N.P. Buchynska, L.G. Original contributions Aim: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p < 0.001 and 54.5 ± 2.6%, respectively, p < 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin. 2018 Article Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I.P. Nesina, N.P. Iurchenko, L.G. Buchynska // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 218–222. — Бібліогр.: 33 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145637 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Nesina, I.P. Iurchenko, N.P. Buchynska, L.G. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma Experimental Oncology |
| description |
Aim: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p < 0.001 and 54.5 ± 2.6%, respectively, p < 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin. |
| format |
Article |
| author |
Nesina, I.P. Iurchenko, N.P. Buchynska, L.G. |
| author_facet |
Nesina, I.P. Iurchenko, N.P. Buchynska, L.G. |
| author_sort |
Nesina, I.P. |
| title |
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_short |
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_full |
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_fullStr |
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_full_unstemmed |
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_sort |
markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2018 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/145637 |
| citation_txt |
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I.P. Nesina, N.P. Iurchenko, L.G. Buchynska // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 218–222. — Бібліогр.: 33 назв. — англ. |
| series |
Experimental Oncology |
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AT nesinaip markersoftheepithelialmesenchymaltransitionincellsofendometrialcarcinoma AT iurchenkonp markersoftheepithelialmesenchymaltransitionincellsofendometrialcarcinoma AT buchynskalg markersoftheepithelialmesenchymaltransitionincellsofendometrialcarcinoma |
| first_indexed |
2023-05-20T17:22:44Z |
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2023-05-20T17:22:44Z |
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1796153160160509952 |