Биологические особенности серозного рака яичника с учетом экспрессии белка p53 и его модуляторов

• Дата: 2015
• Автори: Несина, И.П., Юрченко, Н.П., Свинцицкий, В.С., Бучинская, Л.Г.
• Формат: Стаття
• Мова: Russian
• Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
• Назва видання: Онкологія
• Теми: Оригинальные исследования
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/145662
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Биологические особенности серозного рака яичника с учетом экспрессии белка р53 и его модуляторов / И.П. Несина, Н.П. Юрченко, В.С. Свинцицкий, Л.Г. Бучинская // Онкологія. — 2015. — Т. 17, № 4. — С. 246-252. — Бібліогр.: 30 назв. — рос.

Aim: this study was devoted to investigate the expression of some regulatory proteins of cell cycle in tumors with p53 high and negative expression, and comparison of these indices with both morphological characteristics of serous ovarian cancer (OC) and patients’ clinical characteristics. Object and methods: samples from operational material of 73 OC patients aged from 36 to 76 years (mean age 50.2 ± 2.6 years), were examined using morphological, immunohistochemical and statistical methods. Results: in serous ovarian tumors with high p53 expression (label index > 30.0%) we observed high expression of MDM2 proteins (56.9 ± 4.5%) and p14ARF (12.1 ± 3.5%), low expression of PTEN (34.8 ± 3.5%) and p21⁵⁵WAF¹/CIP¹ (11.0 ± 1.7%). It was associated with tumor differentiation degree decrease, its proliferative activity (proliferation index 31.7 ± 3.4%) and metastatic potential elevation, and significant reduction in the number of patients with total 5-year survival. In contrast, ovarian tumors with negative p53- expression were low proliferative neoplasms (proliferation index 5.6 ± 1.8%), and were characterized by low expression of MDM2 (35.8 ± 7.5%), p14ARF (2.7 ± 2.0%) and high expression of PTEN (48.0 ± 4.2%) and p21WAF¹/CIP¹ (18.7 ± 4.2%). Conclusion: changes of protein p53 expression in serous OC cells is accompanied by altered expression of its modulators — MDM2 and p14ARF, which is the important feature of these tumors. We can assume that high amounts of p53-, MDM2- and p14ARF-positive cells and decreased amounts of cells with PTEN and р21WAF¹/CIP¹ expression in ovarian malignant tumors probably may serve as predicative indicator of their aggressiveness, as it is associated with low tumor differentiation degree and high proliferative and metastatic potential.