Glatiramer Acetate Treatment-Related Effects on Visual EPs and P300 Wave in Patients Suffering from Multiple Sclerosis

• Дата: 2013
• Автори: Major, Z.Z., Văcăraş, V., Buzoianu, A.D, Mureşanu, D.F.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут фізіології ім. О.О. Богомольця НАН України 2013
• Назва видання: Нейрофизиология
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/148098
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Glatiramer Acetate Treatment-Related Effects on Visual EPs and P300 Wave in Patients Suffering from Multiple Sclerosis / Z.Z. Major, V. Văcăraş, A.D. Buzoianu, D.F. Mureşanu // Нейрофизиология. — 2013. — Т. 45, № 3. — С. 264-272. — Бібліогр.: 26 назв. — англ.

Multiple sclerosis is an inflammatory neurological disease of young adults that leads to numerous therapeutic problems and to severe disability. Glatiramer acetate (GA) is a diseasemodifying drug used frequently for long-term treatment of the disease. We investigated the impact of GA treatment on the parameters of reversal-pattern visual evoked potentials and event-related P300 wave (reflecting visual acuity and cognitive dysfunction). Relapsingremitting multiple sclerosis patients either subjected to one-year-long continuous treatment with GA or without any disease-modifying therapy and also healthy controls were involved in the study. The above-mentioned parameters were analyzed at two time points, at the first recording and after one year. It was found that GA did not exert a significant influence on the phenomena studied at least during the one-year follow-up. This finding is in contrast to most of the clinical observations.