Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms

• Видавець: Інститут фізіології ім. О.О. Богомольця НАН України
• Дата: 2013
• Автори: Ibironke, G.F., Rasak, K.S.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут фізіології ім. О.О. Богомольця НАН України 2013
• Назва видання: Нейрофизиология
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/148127
• Цитувати: Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms / G.F. Ibironke, K.S. Rasak // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 380-384. — Бібліогр.: 19 назв. — англ.

In experiments on mice, we examined the effects of 3-min-long forced swimming sessions on indices characterizing the state of the nociceptive system. Thirty minutes after the forced swimming episode, significantly lower (P < 0.05) latencies of motor reactions in the hot plate and tail flick tests were observed.At the same time, times of licking the paw within the early and late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became significantly(P<0.05)smaller.Thus,forcedswimming-inducedstressresultsinthedevelopment of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg) and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (P > 0.05) the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acidinduced (writhing) tests. Thus, the histaminergic system is not significantly involved in the mechanisms of forced swimming-induced hypoalgesia.